Tumor Immunity.ppt

1、Tumor Immunity,小组成员 ： 李新秀 方园 梁菊华 武永霞 孙笑天 朱建春 张清华 2007.5,Introduction,Tumor antigen Tumor immune response Mechanism of tumor immune escape Immunotherapy of tumors,Tumor Antigen,the new antigen produced by tumor cells cause cell immune response and humoral immune response,Immune response,Cellular immu

2、ne Humoral immune,T cell Macrophage NK cell,MHC,B7,CD28,TCR,Fas,Fas L,MHC,B7,CD28,TCR,MHC,B7,CD28,TCR,CK,CK,CTL,Th,Th,NK,M,M,Tumor antigen,Others: DC T cell B1 cell neutrophil,HI,1. Complement-fixing antibodies bind to the tumor cell membrane and promote attachment create pores in the membrane cell

3、disruption due to the loss of osmotic and biochemical integrity.,2. ADCC:,Many potential effector cells ,including NK cells ,Macrophages ,granulocytes ,can mediate the lytic event . More efficient in vitro lytic mechanism requiring fewer antibody molecules per cell to kill.,3 . Opsonization of Ab to

4、 Ag Immune complex 5. Interferance of tumor cell adhension, Self-mutation of tumor cells Inhibition of tumor cells to the immune system,Mechanism of Tumor Immune Escape, Self-mutation of tumor cells,Regulation and absence of MHC,Absence of MHC molecules,(2) Diminution of MHC molecules,2. Changes of

5、tumor antigen Covering or blocking of tumor antigens on the surface of the tumor cells Low immunogenicity of tumor antigens and antigenic modulation,tumor cell,T cell,3. Abnormal express of other molecules on the surface of the tumor cells Lack of co-stimulatory molecules Changes of express level of

6、 important adhesion molecules Block the transduction of apoptosis signals,第一信号,MHC,MHC,TCR,CD4+T,共刺激分子 CD28,共刺激分子 B7,肿瘤抗原,第二信号,第一信号,MHC,TCR,CD4+T,共刺激分子 CD28,共刺激分子（沉默型/低免疫原） B7,肿瘤抗原,第二信号,MHC,Inhibition of tumor cells to the immune system,Secrete soluble immune inhibitors 2.Induce the irresponsibility

7、 of tumor infiltration lymphocytes Induce T cell apoptosis Induce T cell anergy 3. Immune stimulation IL-4,IL-10,1.Operation2.Radiacal therapy3.Chemical therapy4.Biological therapy,immunotherapy,Administration of Monoclonal Antibodies,Adoptive (过继性) T-cell therapy,the cells transferred capable of pe

8、rsisting in the host to be effective be treated by the transfer of tumor specific syngeneic T cell require an extended period,There is now substantial experience with adoptive T-cell transfer in humans.,Immunization to tumor antigen,vaccination,Such DC loaded with tumor antigens by a variety of means, including transfection, infection with recombinant viruses, incubation with the tumor protein or peptide, or phagocytosis of apoptotic tumor cells can be inoculated（接种） into th