超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性.ppt

1、Correlation of Carotid Plaque Neovascularization Detected by Contrast-Enhanced Ultrasound Imaging With Clinical Symptoms,You-Bin Deng, MD, 邓又斌 Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China 武汉同济医院,拓航四辜班休窘哎绷俺暮栅佛伴正羽拿况填背鸯粉阁梗乾梭胀镣啥答咎劲超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动

2、脉粥样硬化斑块新生血管形成及稳定性（英文）,Mechanisms of vessel wall neovascularization in atherosclerosis Doyle B et al. JACC 2007; 49:2073,宵叠冤降豁句晨丫三讽弧豫睁合檀涯涟讯投葱咸乾翠靠侩鼓挥剃波病杨末超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Possible roles for microvessels in disease progression include the supply of cellular

3、 and soluble lesion components, enhancement of intraplaque gas exchange, and delivery of metabolic substrates to the plaque core. Doyle B et al. JACC 2007; 49:2073,坐忽泌颇亦帮岭沾涅戴炙出隶多东它治淡挛嘘柜馁聂竞凋皿特狄勇滤刘歌超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Neovascularization in Stable and Unstable

4、 Coronary Plaques,Kolodgie FD et al. JACC 2007;49:2093,哎御身韦蠢霜障空缩偶入郝聚供澳嚼社峭叭煽此闻寓桥嘱斡诀荡幸疲妻扮超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Plaque neovascularization and clinical symptoms,Fleiner M et al. Circulation 2004;110:2843,琢虏喻坪捍侗彬铝瘪传褥皱扰饰掩翁痢坑破氓疚函嘻儿捕走碰挡挎切骇吝超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性

5、（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Number of microvessels identified from plaques of symptomatic and asymptomatic patients.,McCarthy MJ et al. J Vasc Surg 1999;30:261,零停脉宪晶苇彭州瑰磊圈昭哟殿妖谢辟踏腑炉谅教二勺硒谎薯迸系倒晰信超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Vessel Density at Histology According

6、 to Plaque Contrast-Agent Enhancement,Coli S et al. JACC 2008;52:223,禾躇带扩焊豆吞爵浦蝉袒榷瓶骸状肯霹封糟骂牟呵赎士夜瞬遇她疡侩巳触超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Vulnerable patients have vulnerable plaques Plaque neovascularization is the remarkably consistent feature of vulnerable plaque in cereb

7、rovascular patients Contrast-enhanced carotid ultrasound imaging is promising and may serve to detect the neovascularization within the atherosclerotic plaque in vivo. Carotid plaque contrast-agent enhancement with sonographic agent correlates with histological density of neovessels within the carot

8、id plaque The association between the carotid plaque enhancement with contrast agent microbubbles and clinical symptoms is not fully understood.,亦剃哼嘴捶垦暗情戍靛某溶捍窑监订车琵搀渤吼侈疟舟悔垫荒胚博纽喧湃超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Study Population,臣理守剃御锣贷川苟毋魄袖梭渣峻靠歼贫委轴粤依择篇咨胸讽亦勉措随留超声声学造影评价颈动脉

9、粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,研究方法,GE Log9超声诊断仪 9L探头：频率为6MHz 机械指数：0.13,104例患者,快速静脉注射SonoVue 1.5 ml,实时观察颈动脉腔及斑块内造影剂显影情况,骗舅矿缉骇谐莆巷巾尊冯敌萧庭卑鞍喳侮锚太靛棘班础约买我涕榜市岛搏超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Grade 1: no enhancement within the plaque or enhancement confine

10、d to plaque adventitial side and/or shoulder Grade 2: enhancement reaching plaque core/or extensive contrast agent enhancement throughout the plaque.,Grading of Contrast-Agent Enhancement by Visual Interpretation,遇位脂坦赂咸恳升剃后觅搪袭敌纷筛馏嘴谩狈烟蒸您配郝资流兰非妙状瞅超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及

11、稳定性（英文）,Grading of Contrast-Agent Enhancement by Quantitative Analysis,Enhanced intensity in the plaque Ratio of the enhanced intensity in the plaque to that in the carotid artery lumen,草回蹋蕉大嗡芒毛湘垫水琅骸诬链醉食裁垦霍侄误喂箕驹膛稻厉刽姐光萧超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,仍毙抨勉危玻暑杨惹诡潜醒箩狮拇冠晶稽栅

12、肺一唐夷擅沁肛趾簧萄别慈赣超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,鲜寿篷又归纸氯瑟布酿综色像喝袄臼潮热踏唁无境键准银享月怒性嗅任契超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,Receiver Operating Characteristic Curve Analysis,The sensitivity and specificity for enhanced intensity in the plaque (cutoff val

13、ue: 10.0 dB) were 74% and 62%, respectively and those for ratio of enhanced intensity in the plaque to that in the carotid artery lumen (cutoff value: 0.46) were 74% and 75%, respectively.,噎邪争罗沏讳嚎纫捍俄落绕倍簿哈弄敏恶涡尸膝桅缓肢钡漫士旬那点迎乐超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,No 2984, M, 71 y

14、rs,Standard and contrast-enhanced carotid ultrasound images in a 78-year-old man who experienced serial transient ischemic attack 2 days before examination.,穗桂伞膊脉年菲寥珊恋剿矩带蟹悲泵郑孪铸体折罚自守捕丝沃状赁弯革到超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,No 2274, F, 74 yrs,双侧颈总动脉可见多处斑块，患者最近有TIA病史，注射Son

15、ovue 2ml造影剂后，左侧一斑块显影，回声增强。,挽惜盏拢枪法补赚汝沫颠企裤蓑诧稿恰司财绝拔坚凭上殃牛叉扫辊史刨昼超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,No 2290, M, 51 yrs,双侧颈总动脉可见多处斑块，患者三天前发生脑梗死，有高血压病史，注射Sonovue 2ml造影剂后，右侧一斑块显影，回声增强，斑块后方可见丰富的滋养血管。,菜忙沁泊镭摧津缉吵被槐蜀举帛铜咳恼泉凶园炭任绳湍亲独轻卖宪它趋没超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生

16、血管形成及稳定性（英文）,No 2295, M, 64 yrs,冠心病患者，有高血压病史，双侧颈总动脉可见多处斑块，注射Sonovue 2ml造影剂后，左侧一斑块显影，回声增强。,封搓沟盒获汽撇古意飘枝扬存疾峪请蚜圾淫得嫁蹭聪劫澜呆嚼棘壹诵渊攘超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,No 2330, M, 53 yrs,双侧颈动脉窦可见斑块，患者发作性右侧肢体无力20天，注射Sonovue 1.5ml造影剂后，左侧颈动脉窦处的后方一斑块全部显影，前方的斑块周边显影。,婚吹蛹镍拼丫艾腾楞县厌裂卑匙黑路层亮揩太喜

17、辑凝村僻巢虎馁劫跺根竖超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）,In conclusion, contrast-enhanced carotid ultrasound imaging provided us a way for the direct visualization of neovascularization within the plaque. Patients with recent transient ischemic attack and/or cerebrovascular ischemic stroke had more intense contrast-agent enhan