生物化学(英文版)教学大纲

1、生物化学（英文版）教学大纲课程编号：15010003总学时数：86学时（另有实验教学33学时）学分：5学分一、课程性质、目的和要求生物化学是生物科学和生物技术专业的一门重要的必修专业基础课。学习和掌握生物化学的基本理论和技术对于其它生物学科的学习及今后的相关工作都具有十分重要的意义。开展生物化学双语教学的目的是使学生在系统学习和掌握生物化学的理论和和实践知识的同时，更好地掌握和应用专业外语，培养成具有国际合作意识、国际交流与竞争能力的外向型人才。鉴于生物化学是一门知识涉及面广，复杂程度高的学科，所以，我们将生物化学双语教学分为不同层次开设，即基础生物化学和高级生物化学的双语教学。在基础生物化学

2、的双语教学中，着重要求学生学习和掌握生物化学的基本理论、基本知识和基本原理；同时也要求了解一些本学科发展前沿的新理论、新动向，使学生打下生物化学基本理论和知识的坚实基础，适应以后的高级生物化学双语教学及相关学科的学习。同时，采用原版英文生化教材，有利于学生尽快接触生化发展的新知识，扩大知识面，提高学生阅读英文专业文献的能力，适应生物化学的高速发展。不仅使学生获得较为广博的生物化学基本理论和基础知识，而且使学生初步树立科学的世界观和人生观，学会用辩证唯物主义的正确观点认识生命的现象和本质，从而使学生进一步学习和工作打下坚实的基础。二、教学内容、要点和课时安排本课程的教学内容共分十三章。 sect

3、ion a cell organization 5课时 a1 prokaryotes a2 eukaryotes a3 microscopy a4 cellular fractionationsection b amino acids and proteins 9课时 b1 amino acids b2 acids and bases b3 protein structure b4 myoglobin and hemoglobin b5 collagen b6 protein purification b7 chromatography of proteins b8 electrophores

4、is of proteins b9 protein sequencing and peptide synthesissection c enzymes 6课时 c1 introduction to enzymes c2 thermodynamics c3 enzyme kinetics c4 enzyme inhibition c5 regulation of enzyme activitysection d antibodies 6课时 d1 the immune system d2 antibody structure d3 polyclonal and monoclonal antibo

5、dies d4 antibody synthesis d5 antibodies as toolssection e membranes 6课时 e1 membrane lipids e2 membrane protein and carbohydrate e3 membrane transport: small molecules e4 membrane transport: macromolecules e5 signal transudationsection f dna structure and replication 6课时 f1 dna structure f2 chromoso

6、mes f3 dna replication in bacteria f4 dna replication in eukaryotessection g rna synthesis and processing 8课时 g1 rna structure g2 transcription in prokaryotes g3 the lac operon g4 the trp operon g5 transcription in eukaryotes: an overviewg6 transcription of protein-coding genes in eukaryotes g7 regu

7、lation of transcription by rna pol g8 processing of eukaryotic pre-mrna g9 ribosomal rna g10 transfer rnasection h protein synthesis 6课时 h1 the genetic code h2 translation in prokaryotes h3 translation in eukaryotes h4 protein targeting h5 protein glycosylationsection i recombinant dna technology 6课

8、时 i1 restriction enzymes i2 nucleic acid hybridization i3 dna cloning i4 viruses i5 dna sequencing i6 polymerase chain reactionsection j carbohydrate metabolism 10课时 j1 monosaccharides and disaccharides j2 polysaccharides and oligosaccharides j3 glycolysis j4 gluconeogenesis j5 pentose phosphate pat

9、hway j6 glycogen metabolism j7 control of glycogen metabolismsection k lipid metabolism 6课时 k1 structures and roles of fatty acids k2 fatty acid breakdown k3 fatty acid synthesis k4 triacylglycerols k5 cholesterol k6 lipoproteinssection l respiration and energy 6课时 l1 citric acid cycle l2 electron t

10、ransport and oxidative phosphorylation l3 photosynthesissection m nitrogen metabolism 6课时 m1 nitrogen fixation and assimilation m2 amino acid metabolism m3 the urea cycle m4 hemes and chlorophylls三、教学方法 采用英文原版教材，实行双语教学，制作ppt课件，利用多媒体技术和适当的板书辅助教学。四、成绩考核方式 课程结束后以闭卷、笔试形式进行考试。英文出题，鼓励英文答卷，结合平时成绩计算总分。五、教材与

11、主要参考书目教材：b.d.hames等编著，biochemistry(第二版)，科学出版社，2003年主要参考书目：1h. r. horton, l. a. moran, r. s. ochs, j. d. rawn, k.g.scrimgerour. principles of biochemistry (third edition). science press and pearson education north asia limited. 20022. trudy mckee, james r. mckee. biochemisry: an introduction (second

12、editon). mcgraw-hill companies, inc. 20013. william j, lennarz, m.daniel lane. encyclopedia of biological chemistry. elsevier pte ltd. 20044. lehninger principles of biochemistry, third edition, david l. nelson and micheal m. cox, worth publishers, 2000.5. jeremy m. berg, john l. tymoczko, and lubert stryer, biochemistry fifth edition. w.h. freeman and company, 2003.6. trudy mckee and james r. mckee, biochemistry. third edition. the m