临床医学文献检索、阅读、评价与应用+2011.9.15.1.ppt

1、临床医学文献检索、阅读、评价与应用,崔学军 2011年9月15日,检索途径,题录型数据库 中国生物医学文献数据库（CBM） Medline 全文型数据库 中文科技期刊数据库（VIP） 万方数据知识平台 中国知网（CNKI）,Medline检索,保存和跟踪检索结果,获取全文的途径,其他途径,中国科学院上海生命科学研究院 复旦大学上海医学院 上海图书馆 交通大学,Google 题目 英文关键词 filetype:PDF 联系作者 论坛 代理,重要工具,华东地区西文生物医学期刊馆藏联合目录 各家图书馆订阅的外文期刊纸质版 复旦大学医科图书馆有电子检索,阅读的目的,了解临床证据-Cochrane Li

2、brary，Clinical Evidence，高IF SCI论文 最新进展Pubmed-Abstract 研究方法Methods 讲演、兴趣-精读 了解背景-Introduction 相互比较-Discussion 评价质量-Methods,文章的结构,Title and running title Authors and addresses Abstract Keywords and abbreviations Introduction Materials and methods Results Discussion Acknowledgments References Tables an

3、d figures,Title Abstract Figures Tables Results and discussion Rest of the paper,(J.K. Ladha),影响因子（Impact Factor）,发表文章篇数： 2009=597，2010=577；合计=1174 2011年引用次数： 2009=4341，2010=4122；合计=8463 IF=8463/1174=7.209 2012年6月中下旬公布,文章质量评价,Jadad评分 Cochrane Handbook Cochrane Back Review Group CONSORT声明,Jadad 评分,随机

4、分组序列的产生方法 2分：计算机或随机数字表 1分：提到随机，但未详细说明 0分：半随机或未随机 双盲 2分：描述了实施双盲的具体方法并且被认为是恰当的，如采用完全一致的安慰剂等 1分：试验仅提及采用双盲法 0分：试验提及采用双盲，但方法不恰当，如比较片剂与注射剂而未提及使用双伪法 退出与失访 1分：详细说明了退出与失访的理由 0分：没有提及,Cochrane Back Review Group,Furlan AD, Pennick V, Bombardier C, van Tulder M, the Editorial Board of the Cochrane Back Review Gr

5、oup. 2009 Updated method guidelines for systematic reviews in the Cochrane Back Review Group. Spine 2009;34(18):192941.,CONSORT清单详细内容,引言,Broad information on topic Previous research Narrower background information Need for study Focus of paper Hypothesis and Purpose,Surgery is the treatment of choic

6、e for patients with disease stage I and II non-small cell lung cancer (NSCLC) An NSCLC meta-analysis combined the results from eight randomised trials of surgery versus surgery plus adjuvant cisplatin-based chemotherapy and showed a small, but not significant (p=0.08), absolute survival benefit of a

7、round 5% at 5 years (from 50% to 55%). At the time the current trial was designed (mid-1990s), adjuvant chemotherapy had not become standard clinical practice The clinical rationale for neo-adjuvant chemotherapy is three-fold: regression of the primary cancer could be achieved thereby facilitating a

8、nd simplifying or reducing subsequent surgery; undetected micro-metastases could be dealt with at the start of treatment; and there might be inhibition of the putative stimulus to residual cancer by growth factors released by surgery and by subsequent wound healing The current trial was therefore se

9、t up to compare, in patients with resectable NSCLC, surgery alone versus three cycles of platinum-based chemotherapy followed by surgery in terms of overall survival, quality of life, pathological staging, resectability rates, extent of surgery, and time to and site of relapse.,CONSORT清单详细内容,CONSORT

10、清单详细内容（续一）,CONSORT清单详细内容（续二）,CONSORT清单详细内容（End）,CONSORT Group. CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomized Trials. Ann Intern Med. 2010;152. David Moher, et al. CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 2010;340:c869,CONSORT流程图,好文章的要求（4C）,Clear：思路清晰、逻辑性强、概念清楚、层次 清楚、表达清楚、语句通顺 Complete：内容完整、结构完整，忌虎头蛇尾 Correct：内容正确，数据数据正确、可信， 文法正确 Conci