Oleic-acid-9-cis-Octadecenoic-acid-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOleic acidCat. No.: HY-N1446CAS No.: 112-80-1Synonyms: 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid分式: CHO分量: 282.46作靶点: Na+/K+ ATPase; Endogenous Metabolite作通路: Membrane Transporter/Ion Channel; MetabolicEnzyme/Protease储存式: Pu

2、re form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (221.27 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.5403 mL 17.7016 mL 35.4032 mL5 mM 0.7081 mL 3.5403 mL 7.0806 mL10 mM 0.3540 mL 1.7702 mL 3.5403 mL请根据产

3、品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.36 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (2

4、0% SBE-CD in saline)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (7.36 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (7.36 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Oleic acid脂 细胞和其他组织中最常见的单不饱和脂 酸 1。Oleic acid 种 Na+/K+ ATP酶激活剂2。IC50 & Target

5、Human Endogenous Metabolite体外研究 Oleic acid is the most common monounsaturated fatty acids (FA) in human adipocytes and other tissues.Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing -oxidationmediated by AMPK activation. Oleic acid inhibits cancer cel

6、l growth and survival in low metastatic carcinomacells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines 1.户使本产品发表的科研献 Cell Death Dis. 2019 May 28;10(6):416. J Exp Clin Cancer Res. 2019 Jul 10;38(1):300.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Li S

7、, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May13;9(5):e97330.2. Jack-Hays MG, et al. Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship.Biochim Biophys Acta. 1996 Feb 21;1279(1):43-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research