纳米技术在医学应用方面的全球市场分析报告

MARKET RESEARCH REPORT NANOTECHNOLOGY IN MEDICAL APPLICATIONS: THE GLOBAL MARKET HLC069A Paul Evers Project Analyst BCC Research 35 Walnut Street Wellesley, MA 02481 Phone: 866-285-7215 (sales) Web Address: E-mail: ISBN: 1-59623-548-9 ii HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS ABOUT BCC BCC Research is a leading information resource producing high-quality market research reports, newsletters, and conferences. BCC s information products explore major market, economic, scientific, and technological developments for business leaders in industrial, pharmaceutical, and high technology organizations. Industry analysis and market forecasts for advanced materials, high-tech systems and components, nanotechnology and novel processing methods are at the forefront of the company s expertise. For more than 35 years, BCC s market analysis has provided businesses with the insight needed to make intelligent and strategic business decisions. 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To receive a complete catalog of BCC studies, please visit our Web site at JANUARY 2010 Copyright BCC Research, Wellesley, MA USA Web: iii HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS CHAPTER ONE: INTRODUCTION 1 STUDY GOALS AND OBJECTIVES. 1 REASONS FOR DOING THE STUDY 1 INTENDED AUDIENCE 1 SCOPE OF REPORT 2 MARKET ANALYSES AND FORECASTS . 2 METHODOLOGY . 2 INFORMATION SOURCES . 2 ANALYST CREDENTIALS 3 RELATED BCC REPORTS 3 BCC ONLINE SERVICES 3 DISCLAIMER . 3 CHAPTER TWO: SUMMARY 4 RESEARCH AND COMMERCIALIZATION 4 APPLICATIONS. 4 DRUG DELIVERY . 4 DRUGS AND THERAPY . 5 IN VIVO IMAGING 5 IN VITRO DIAGNOSTICS 5 BIOMATERIALS 5 ACTIVE IMPLANTS 5 MARKET 5 SUMMARY TABLE NANOMEDICAL GLOBAL SALES BY THERAPEUTIC AREA, THROUGH 2014 ($ BILLIONS). 6 SUMMARY FIGURE NANOMEDICAL GLOBAL SALES BY THERAPEUTIC AREA, 2006-2014 ($ BILLIONS) 6 CHAPTER THREE: OVERVIEW 7 MEDICAL NANOTECHNOLOGY: NANOMEDICINE 7 FUTURE POSSIBILITIES . 7 MARKET POTENTIAL 8 ABOUT NANOTECHNOLOGY . 8 ABOUT NANOTECHNOLOGY (CONTINUED) 9 THE MANY USES OF NANOTECHNOLOGY . 10 MEDICAL APPLICATIONS 10 ENVIRONMENTAL APPLICATIONS 10 MILITARY APPLICATIONS. 11 COSMETICS 11 APPLICATIONS IN DEVELOPMENT . 11 THE TOOLS OF NANOTECHNOLOGY. 12 Copyright BCC Research, Wellesley, MA USA Web: iv HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS C60/FULLERENES 12 CARBON NANOTUBES 12 NANOPARTICLES 12 NANOWIRES . 13 MOLECULAR NANOTECHNOLOGY 13 RISKS OF NANOTECHNOLOGY . 13 POISON/TOXICITY . 13 NANOTECHNOLOGY IN THE MARKETPLACE . 14 NANOTECHNOLOGY IN (CONTINUED) 15 NANOTECHNOLOGY IN (CONTINUED) 16 CHAPTER FOUR: NANOMEDICINE. 17 DEVELOPMENT OF NANOMEDICAL TECHNOLOGIES. 17 TABLE 1 NANOMEDICINE TIMESCALE 17 TABLE 2 MAIN NANOTECHNOLOGIES USED IN MEDICINE, WITH APPLICATIONS 18 LIPOSOMES 18 TABLE 3 MARKETED LIPOSOME NANOPHARMACEUTICALS 19 DENDRIMERS. 20 TABLE 4 DENDRIMER PRODUCTS IN ADVANCED DEVELOPMENT . 20 NANOCRYSTALS 20 TABLE 5 NANOCRYSTAL PHARMACEUTICALS 21 MICELLES . 21 TABLE 6 MARKETED AND DEVELOPMENTAL PRODUCTS IN MICELLE FORM . 22 FULLERENES . 22 POLYMERIC NANOPARTICLES. 23 THERAPEUTIC USES OF NANOMEDICINE . 24 CANCER DIAGNOSTICS AND THERAPY . 24 Silica Nanospheres 24 Nanoscale Hydrogel Shells 24 Photodynamic Therapy and Gold 25 Dendrimer Conjugates 26 Ligand-targeted Emulsion Technologies 26 Linear Cyclodextrin-containing Polymers 27 Smart Lipid-based Nanocarriers 27 Thermotherapy Using Magnetic Nanoparticles. 28 Targeted Cell Destruction . 28 Nanoshells 29 DRUG DELIVERY . 29 Acusphere. 29 Copyright BCC Research, Wellesley, MA USA Web: v HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS AlphaRx 30 Aphios. 30 Biodelivery Sciences 30 Bioral 31 Capsulution NanoScience 31 HealthPlus International 32 IGI 32 Labopharm. 32 MagnaMedics. 33 Nanocopoeia . 33 Nanocrystal 33 NanoMed 34 Nanopharm 34 Nanocyte 35 Nanotherapeutics 35 Nanotrope 36 pSivida . 36 SoluBest . 37 Spherics 37 Telemolecular. 37 INFECTION CONTROL 38 Silver Nanoparticles Against Infection. 38 Detecting Nanobacteria. 39 Killing Viruses . 40 DIAGNOSTIC TOOLS . 40 BioCrystal/InVitrogen . 40 BioForce . 41 Biophage. 41 CombiMatrix 41 Farfield Sensors. 42 GE Healthcare BioSciences. 42 Immunicon . 43 MagnaMedics. 43 Nanogen . 44 NanoSphere . 44 Qiagen 45 Sphere 45 TransGenex 46 Veredus 46 VARIOUS THERAPEUTIC TARGETS AND TECHNOLOGIES 47 Anthrax 47 Copyright BCC Research, Wellesley, MA USA Web: vi HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS Cholesterol . 47 Artificial Retina . 47 Nerve Regeneration. 48 Crossing the Blood-Brain Barrier . 48 Protecting Against Radiation Damage . 49 Antibody Therapeutics 50 Hemostasis. 50 Bone Fracture Repair 51 Dental Implant and Tissue Regeneration 51 Vaccine Adjuvant 51 Treatment of Thrombosis 52 Coatings for Stents and Other Devices. 53 FUTURE TRENDS AND RESEARCH POSSIBILITIES. 53 Noninvasive Nanodevices 54 Extracellular Devices 55 Intracellular Devices . 55 Nanomachines to Control Tissue Healing 56 Eliminating Viruses 57 Correcting Chemistry 58 New Organs and Limbs. 58 FUNDAMENTAL NANOTECHNOLOGY RESEARCH 58 U.S 59 University at Albany-SUNY. 59 Cornell University 59 University of Michigan . 60 Rice University 60 University of Pennsylvania 61 University of Virginia . 62 University of North Carolina . 62 Ohio State University . 63 Northwestern University 63 University of Pittsburgh. 63 Case Western Reserve University 64 University of California at Berkeley 64 Europe 64 TABLE 7 EUROPEAN NANOCENTERS. 65 Japan 65 Development of Active Targeting DDS 66 Development of Novel Tissue Engineering 66 Development of New Biomaterials. 66 THE RISK FACTOR . 67 Copyright BCC Research, Wellesley, MA USA Web: vii HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS MARKETS FOR NANOMEDICINE 68 TABLE 8 MARKETED NANOPHARMACEUTICALS 69 TABLE 9 MARKETED NANO-IMAGING, DIAGNOSTICS, BIOMATERIALS . 70 MARKET DRIVERS. 70 MARKET ESTIMATES AND FORECASTS . 71 TABLE 10 NANOTECHNOLOGY REVENUES BY INDUSTRY SECTOR, 2010 (%) 71 Global Nanomedicine Market . 72 TABLE 11 GLOBAL NANOMEDICINE MARKET, THROUGH 2014 ($ BILLIONS) . 72 Main Product Categories. 72 Drug Delivery 72 Molecular Diagnostics. 73 Market Analysis by Clinical Application 74 Cancer 74 TABLE 12 MAJOR MARKETED ANTICANCER NANOPHARMACEUTICALS, 2008 ($ BILLIONS) 74 TABLE 13 MARKET FORECAST FOR CANCER NANOTHERAPEUTICS AND ANODIAGNOSTICS, THROUGH 2014 ($ BILLIONS). 75 CNS Disorders 75 TABLE 14 MAJOR MARKETED CNS NANOPHARMACEUTICALS, 2008 ($ MILLIONS) 75 TABLE 15 MARKET FORECAST FOR CNS NANOMEDICINES, THROUGH 2014 ($ BILLIONS) . 76 Infection. 76 TABLE 16 MAJOR MARKETED ANTI-INFECTIVE NANOPHARMACEUTICALS, 2008 ($ BILLIONS). 76 TABLE 17 MARKET FORECAST FOR ANTI-INFECTION NANOTHERAPEUTICS AND NANODIAGNOSTICS, THROUGH 2014 ($ BILLIONS). 77 Cardiovascular and Autoimmune Disorders . 77 TABLE 18 MAJOR MARKETED NANOMEDICINES FOR CARDIOVASCULAR AND INFLAMMATORY DISEASES, 2008 ($ MILLIONS) 77 TABLE 19 MARKETS FOR CARDIOVASCULAR AND ANTI- INFLAMMATORY PRODUCTS, THROUGH 2014 ($ BILLIONS) 78 Regional and National Market Analysis 78 FIGURE 1 NATIONAL SHARES OF THE GLOBAL NANOMEDICINE MARKETPLACE, 2009 (%) 78 Copyright BCC Research, Wellesley, MA USA Web: viii HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS FIGURE 1 (CONTINUED) . 79 U.S. 79 TABLE 20 U.S. NANOMEDICINE MARKET: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%). 79 Japan . 80 TABLE 21 NANOMEDICINE MARKET IN JAPAN: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%). 80 Europe . 81 TABLE 22 NANOMEDICINE MARKET IN GERMANY: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%). 81 TABLE 23 NANOMEDICINE MARKET IN FRANCE: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%). 81 TABLE 24 NANOMEDICINE MARKET IN UNITED KINGDOM: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%) 82 TABLE 25 NANOMEDICINE MARKET IN ITALY: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%). 82 TABLE 26 NANOMEDICINE MARKET IN SPAIN: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLION/%) . 82 Europe (Continued) 83 CHAPTER FIVE: COMPANY PROFILES 84 ABLYNX NV . 84 ABRAXIS BIOSCIENCE 85 ABRAXIS BIOSCIENCE (CONTINUED). 86 ACRYMED INC. . 87 ACUSPHERE INC. . 88 ACUSPHERE INC. (CONTINUED) 89 ADVANCED MAGNETICS 90 ALLTRACEL . 90 ALPHARX INC. 91 ALPHARX INC. (CONTINUED) . 92 ANSON NANO-BIOTECHNOLOGY . 93 APHIOS CORP 93 PROTEIN NANOPARTICLES 94 POLYMER NANOSPHERES 94 PHOSPHOLIPID NANOSOMES 94 BIOCRYSTAL LTD. 95 BIOFORCE NANOSCIENCES INC. . 96 THE VIRICHIP VIRUS DETECTION PLATFORM 96 BIO-GATE AG. 97 Copyright BCC Research, Wellesley, MA USA Web: ix HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS MEDICAL APPLICATIONS 98 BIOPHAGE PHARMA INC. . 99 PRODUCTS 99 DEVELOPMENT THROUGH COLLABORATIONS: 99 PHAGES . 100 BIOPHAN TECHNOLOGIES 101 BIOSANT PHARMACEUTICALS INC. 102 NOVEL VACCINE ADJUVANT BIOVANT 102 THERAPEUTIC DRUG DELIVERY PLATFORMBIOAIR /BIOORAL . 103 CALANDO PHARMACEUTICALS 104 C SIXTY. 105 C SIXTY (CONTINUED) 106 CAPSULUTION PHARMA AG 107 DRUG DELIVERY SYSTEMS. 107 COMBIMATRIX 108 DRUG DEVELOPMENT . 108 Drug Development (Continued) 109 DAMAGE PREVENTION CONCEPT . 110 ELAN DRUG TECHNOLOGIES . 110 ELAN DRUG TECHNOLOGIES (CONTINUED) 111 FARFIELD SCIENTIFIC . 112 FARFIELD SCIENTIFIC (CONTINUED) 113 GE HEALTHCARE LIFE SCIENCES . 114 HEALTHPLUS INTERNATIONAL INC. 115 IGI INC 116 IMARX THERAPEUTICS INC. . 117 SONOLYSIS . 118 JR NANOTECH PLC 119 KEREOS, INC. 119 MRI AGENT FOR TUMOR DETECTION 120 TARGETED CHEMOTHERAPEUTICS FOR SOLID TUMORS 120 KI-0002 MRI AGENT FOR CARDIOVASCULAR DISEASE DETECTION. 120 ANTI-RESTENOTIC 120 KEYSTONE NANO, INC. 121 NANOJACKETS 121 KLEINDIECK NANOTECHNIK . 122 NANOWORKSTATION . 122 LABOPHARM INC. 123 LABOPHARM INC. (CONTINUED) 124 Copyright BCC Research, Wellesley, MA USA Web: x HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS LIPLASOME PHARMA 125 LIPLASOME PHARMA (CONTINUED) . 126 LUMERA CORPORATION 127 NANOCAPTURE MICROARRAYS. 128 MAGFORCE NANOTECHNOLOGIES AG. 128 MAGFORCE NANOTECHNOLOGIES AG (CONTINUED) 129 MAGNAMEDICS GMBH . 130 MAGCUSTOM 130 Customized Nano- and Micro-Particles 130 EFFICIENT AND LOW-COST DIAGNOSTICS. 131 MULTIFUNCTIONAL DRUG CARRIER . 131 MICROFLUIDICS INTERNATIONAL CORPORATION. 132 MIV THERAPEUTICS INC. 133 CARDIOVASCULAR HEART STENTS 134 MOLECULAR PROFILES . 135 NANOBAC PHARMACEUTICALS INC . 136 NANOBIO CORPORATION. 137 NANOBIO CORPORATION (CONTINUED) . 138 NANOBIO CORPORATION (CONTINUED) . 139 NANOBIOTIX . 140 NANOBIOTIX (CONTINUED) 141 NANOCARRIER CO. LTD. 142 NANOCARRIER CO. LTD. (CONTINUED) . 143 NANOCOPOEIA . 144 NANOCYTE INC 145 NANOGEN INC. . 146 ELECTRONIC MICROARRAY . 147 INSTRUMENTATION. 147 Molecular Biology Workstation. 147 Molecular Biology Workstation Cartridge 148 NanoChip 400 System . 148 NANOINK INC. 149 NANOLOGIX INC. . 150 NANOMED PHARMACEUTICALS, INC. 151 NANOMIX INC. 152 NANOPHARM AG 153 NANOSPECTRA BIOSCIENCES, INC. 154 NANOSPHERE INC. 155 NANOSPHERE INC. (CONTINUED). 156 NANOSTRUCTURES INC. 157 NANOSYN INC. 158 Copyright BCC Research, Wellesley, MA USA Web: xi HLC069A Nanotechnology in Medical Applications: The Global Market TABLE OF CONTENTS NANOTHERAPEUTICS INC. 159 NANOTHERAPEUTICS INC. (CONTINUED) 160 NANOTROPE INC 161 NANOVIRICIDES INC. 162 FLUCIDE-I . 162 NUCRYST PHARMACEUTICALS 163 WEBSITE: WWW.NUCRYST.COM 163 NUCRYST PHARMACEUTICALS (CONTINUED). 164 NUTRALEASE 165 ORION INTEGRATED BIOSCIENCES INC. . 166 GENOMIC SIGNATURES. 166 RATIONAL ANTIVIRAL DEVELOPMENT. 167 DISCOVERY OF MALARIA INVASION PATHWAYS 167 ORTHOVITA INC . 168 PIONEER SURGICAL TECHNOLOGY 169 PSIVIDA LTD . 169 PSIVIDA LTD (CONTINUED) 170 QIAGEN N.V. 171 SOLUBEST LTD. 172 SOLUBEST LTD. (CONTINUED) 173 SPHERICS INC. . 174 STARPHARMA HOLDINGS LTD . 175 DENDRIMER NANOTECHNOLOGY 175 TECAN GROUP LTD. 176 TEMOLECULAR CORPORATION . 177 TEMOLECULAR CORPORATION (CONTINUED) 178 TEMOLECULAR CORPORATION (CONTINUED) 179 TRANSGENEX NANOBIOTECH INC. . 180 THERAPY. 181 APPENDIX: GLOSSARY OF TERMS . 182 TABLE 27 GLOSSARY OF TERMS . 182 TABLE 27 (CONTINUED) 183 TABLE 27 (CONTINUED) 184 Copyright BCC Research, Wellesley, MA USA Web: xii HLC069A Nanotechnology in Medical Applications: The Global Market LIST OF TABLES SUMMARY TABLE NANOMEDICAL GLOBAL SALES BY THERAPEUTIC AREA, THROUGH 2014 ($ BILLIONS) 6 TABLE 1 NANOMEDICINE TIMESCALE. 17 TABLE 2 MAIN NANOTECHNOLOGIES USED IN MEDICINE, WITH APPLICATIONS. 18 TABLE 3 MARKETED LIPOSOME NANOPHARMACEUTICALS. 19 TABLE 4 DENDRIMER PRODUCTS IN ADVANCED DEVELOPMENT . 20 TABLE 5 NANOCRYSTAL PHARMACEUTICALS 21 TABLE 6 MARKETED AND DEVELOPMENTAL PRODUCTS IN MICELLE FORM . 22 TABLE 7 EUROPEAN NANOCENTERS . 65 TABLE 8 MARKETED NANOPHARMACEUTICALS. 69 TABLE 9 MARKETED NANO-IMAGING, DIAGNOSTICS, BIOMATERIALS 70 TABLE 10 NANOTECHNOLOGY REVENUES BY INDUSTRY SECTOR, 2010 (%) 71 TABLE 11 GLOBAL NANOMEDICINE MARKET, THROUGH 2014 ($ BILLIONS) . 72 TABLE 12 MAJOR MARKETED ANTICANCER NANOPHARMACEUTICALS, 2008 ($ BILLIONS) 74 TABLE 13 MARKET FORECAST FOR CANCER NANOTHERAPEUTICS AND ANODIAGNOSTICS, THROUGH 2014 ($ BILLIONS) . 75 TABLE 14 MAJOR MARKETED CNS NANOPHARMACEUTICALS, 2008 ($ MILLIONS) 75 TABLE 15 MARKET FORECAST FOR CNS NANOMEDICINES, THROUGH 2014 ($ BILLIONS) 76 TABLE 16 MAJOR MARKETED ANTI-INFECTIVE NANOPHARMACEUTICALS, 2008 ($ BILLIONS). 76 TABLE 17 MARKET FORECAST FOR ANTI-INFECTION NANOTHERAPEUTICS AND NANODIAGNOSTICS, THROUGH 2014 ($ BILLIONS) . 77 TABLE 18 MAJOR MARKETED NANOMEDICINES FOR CARDIOVASCULAR AND INFLAMMATORY DISEASES, 2008 ($ MILLIONS). 77 TABLE 19 MARKETS FOR CARDIOVASCULAR AND ANTI- INFLAMMATORY PRODUCTS, THROUGH 2014 ($ BILLIONS) . 78 TABLE 20 U.S. NANOMEDICINE MARKET: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%) 79 TABLE 21 NANOMEDICINE MARKET IN JAPAN: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%) 80 Copyright BCC Research, Wellesley, MA USA Web: xiii HLC069A Nanotechnology in Medical Applications: The Global Market LIST OF TABLES TABLE 22 NANOMEDICINE MARKET IN GERMANY: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%) 81 TABLE 23 NANOMEDICINE MARKET IN FRANCE: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%) 81 TABLE 24 NANOMEDICINE MARKET IN UNITED KINGDOM: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%) 82 TABLE 25 NANOMEDICINE MARKET IN ITALY: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLIONS/%) 82 TABLE 26 NANOMEDICINE MARKET IN SPAIN: HISTORIC AND FORECAST DATA, THROUGH 2014 ($ BILLION/%). 82 TABLE 27 GLOSSARY OF TERMS 182 Copyright BCC Research, Wellesley, MA USA Web: xiv HLC069A Nanotechnology in Medical Applications: The Global Market LIST OF FIGURES SUMMARY FIGURE NANOMEDICAL GLOBAL SALES BY THERAPEUTIC AREA, 2006-2014 ($ BILLIONS) 6 FIGURE 1 NATIONAL SHARES OF THE GLOBAL NANOMEDICINE MARKETPLACE, 2009 (%) 78 Copyright BCC Research, Wellesley, MA USA Web: in 1 HLC069A Nanotechnology in Medical Applications: The Global Market CHAPTER ONE: INTRODUCTION STUDY GOALS AND OBJECTIVES The aim of this report is to provide detailed market, technology and industry analyses to help readers quantify and qualify the market for prescription drug products incorporating nanotechnology features. Important trends are identified and sales forecasts by product categories and major country markets are provided through 2014; these are based on industry sources and considered assessment of the regulatory environment, healthcare policies, demographics, and other factors that directly affect the nanomedicine-related drug market. The wider economic environment is also taken into account. The report examines strategies employed by companies specializing nanomed