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The association between endometrial polyps and metabolic syndrome Reporter : Dan Liu LOGO 稳定情 绪 增信心 0 1 0 2 0 3 审视仪 表教具 准备 Page 1BackgroundMethodsResultsConclusion Endometrial polyps ： ucommon benign gynaecologic disorders, defined as a localised,pedunculated or sessile overgrowth of the endometrium ua cause of abnormal uterine bleeding in both premenopausal and postmenopausal women. u Risk factors ：hormonal factors, obesity, late menopause, hormone replacement therapy, polycystic ovary syndrome (PCOS), and tamoxifen use. u oestrogen and progesterone regulate endometrial proliferation and differentiation, and endometrial polyps have both oestrogen and progesterone receptors obesity is one of the most important obesity increases aromatase enzyme activity and decreases the amount of sex hormone binding globulin (SHBG), thereby increasing free oestrogen levels. LOGO 稳定情 绪 增信心 0 1 0 2 0 3 审视仪 表教具 准备 Page 2BackgroundMethodsResultsConclusion MetS ： u associated with increased risks of several cancers, including endometrial cancer and breast cancer u insulin resistance (IR) explains of the conditions associated with metabolic syndrome (MetS). Insulin also leads to the increase of insulin-like growthfactor 1 (IGF-1), which plays an important role in cellular proliferation These findings support the hypothesis that there may be a relationship between polyps, IR and MetS. LOGO Page 3 Materials and Methods ： BackgroundMethodsResultsConclusion Study group (with endometrial polyps) Control group (without endometrial polyps) inclusion criteria: hysteroscopic detection and histological confirmation inclusion criteria: absence of endometrial pathology in hysteroscopic and histological evaluation Recorded risk factors AgeWCBMI Blood pressure Lipid Profile Fasting glucose IR LOGO Page 4 MetS diagnostic criteria ： u abdominal obesity (WC 88 cm) u hypertriglyceridemia (triglycerides 1.7 mmol/L), low high-density lipoprotein (HDL) (1.3 mmol/L) u hypertension (HT) (blood pressure 130/85 mmHg) u hyperglycaemia (fasting plasma glucose 6.1 mmol/L). BackgroundMethodsResultsConclusion At least includes the presence of three of the above criteria LOGO Page 5BackgroundMethodsResultsConclusion MetS and IR incidence were significantly higher in the study group The presence of MetS was an independent risk factor for endometrial polyp development LOGO Page 6BackgroundMethodsResultsConclusion MetS is characterised by central obesity, HT, hyperglycaemia, IR, and hyperlipidaemia; women with MetS have an increased risk of cardiovascular disease and DM during their lifetime. MetS, a known risk factor for several tumours, displays proliferative oestrogen activity. Endometrial polyps caused by the proliferation of endometrial glands and stroma are often benign lesions that contain both oestrogen and progesterone receptors, Oestrogen exerts mitogenic effects on polyps that are similar to those in normal endometria LOGO Page 6BackgroundMethodsResultsConclusion By examining the components of MetS separately, and it demonstrated that the frequency of increased WC, HT, DM, IR, and MetS was significantly higher in patients with polyps. MetS was found to be an independent risk factor for endometrial polyps. The data suggest that there may be an association between endometrial polyps and MetS with IR. Obese women with polyps should be assessed for risk of MetS, as well as those with PCOS, DM and HT. These women should be made aware about