尿毒症患者的血管钙化机制浅谈课件

LOGO 尿毒症患者的血 管钙化机制浅谈 研一 韩佩桐 LOGO 概述 v为何尿毒症患者的血管钙化发生率高？ u 尿毒症患者的钙磷代谢紊乱是血管钙化的主要危险因素。 钙磷代谢紊乱组织主动调节 血管平滑肌细胞介导； 多种促进及抑制钙化因素 参与 主动的、可调控的生物学 过程 血管发生钙化 LOGO 目录 血管钙化的概况1 尿毒症患者钙磷代谢紊乱2 Click to add Title 3 Click to add Title 4 LOGO 血管钙化 定义 血管钙化是指发生于心血管系统软组织内的 不适当的生物钙化（典型为磷酸钙盐沉积，绝 大多数以羟基磷灰石的形式存在） 分类 根据发生 于血管壁 的部位不 同 中膜钙化 内膜钙化 与血管平滑肌细胞及弹性硬蛋白相关。 无炎性细胞浸润及脂质沉积的环境中,动 脉中膜的弹力层出现线性沉积的羟基磷 灰石晶体钙 可以独立地存在于动脉硬化之外 与脂质、巨噬细胞、血管平滑肌有关 发生在动脉硬化斑块中，脂质条纹期 即可发生,表现为小而弥散分布的羟 基磷灰石晶体钙沉积 可以独立出现,也可以混合存在 LOGO 血管钙化 机制 血管钙化是与 衰老伴随的退行 性病变，使体内 钙磷代谢紊乱所 知钙磷结晶沉积 于细胞和组织间 的被动过程 u在血管钙化灶中可以找到大量骨形成的调节因子 和骨结构蛋白，提示血管钙化是一个主动的、可调 控的生物学过程。 u与骨组织的骨化过程有相似之处，包括基质小泡 的出现、细胞内碱性磷酸酶（ALP）活性增加以及 血管细胞发生成骨细胞样表性转换等。 u表现为钙化促进机制超过钙化抑制机制 最近研究过去认为 LOGO 尿毒症患者的钙磷代谢紊乱 Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text 高磷血症 LOGO Diagram 50% 24% 10% 16% 50% 24% 16% 10% Products Description of the companys products Service Description of the companys service Technology Description of the companys technology Market Description of the companys market LOGO Marketing Diagram ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. Description of the contents Description of the contents Contents textContents text Contents Title (2006) LOGO Diagram 1. Describe contents for a Chart Description of the companys sub contents Description of the companys sub contents 2. Describe contents for a Chart Description of the companys sub contents Description of the companys sub contents Chart Title in here LOGO Diagram Products Description of the companys products Service Description of the companys service Technology Description of the companys technology Market Description of the companys marketText Text Text Text Title Add your text LOGO Diagram Add your text in here Your text in here Your text in here Your text in here Add your text in here Your text in here Your text in here Your text in here ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. LOGO Diagram Text in here 01.Title01.Title Add your text in here Add your text in here Add your text in here 02.Title02.Title Add your text in here Add your text in here Add your text in here 03.Title03.Title Add your text in here Add your text in here Add your text in here ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. LOGO Diagram 1. Description of the products 2. Description of the business Description of the business 1. Description of the products 2. Description of the business Description of the products 1. Description of the products 2. Description of the business Text in here Text in hereText in here Text in here Text in here LOGO Diagram Text in here ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. Text in here ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. Text in here ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. Text in hereText in hereText in here LOGO Progress Diagram Your text in here Your text in here Your text in here Your text in here Your text in here Your text in here Text in here Add your text in here Add your text in here LOGO 3-D Pie Chart Add your text Add your text Add your text Add your text Add your text YourYour SloganSlogan herehere LOGO Diagram 10% 5% 60% 25% ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. Text in here Text in here Text in here Text in here Your text in here Your text in here Your text in here Your text in here Your text in here Your text in here Your text in here Your text in here Your text in here Click to add Text Your text in here Your text in here Your text in here LOGO Diagram Text in hereText in here Text in here Text in here Text in here ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. Add your text in here LOGO Diagram ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. LOGO Diagram Your text in here Your text in here Your text in here Your text in here Your text in here Click to add Title Click to add Title Click to add Title C