低密度脂蛋白、脂蛋白(A)与冠心病.doc

5(CHD)(4SWOSCARELIPIDAFCAPS) (TC) (LDL-C)CHD()CHD CHDLDL-C1CHDLDL-C2 LDL-CLDL (As)LDL AustinLDL AB3BLDLCHD LDL LDL As (a)Lp(a) LDL LDL apoB100apo(a)Asapo(a)AsLDLLp(a)CHDLDL LDLLDLLp(a)CHD LDLLDL(sLDL) ()sLDL(TG)3 Grundy4sLDLTG(HDL-C) ()(lipid triad)As(ALP)5 sLDLTG TGTG (TRL)(IDL)TGIDLsLDLHDL-CAs sLDLAsHokanson6sLDLAs(1)sLDL As(TG)(2)sLDL (3)sLDL(4)sLDLLDL(5)sLDL(6)sLDLAs LDLAs10CHDLDL LDL-CapoBLDLLDL(buoyancy)LDLAs(regression)(37%P0.01)LDLLDL !-empirenews.page-apoBsLDL sLDLLDLBLDLsLDLLDLsLDLap oBBLDLALDLapoB12%23%6BLDLLDL-CapoBLDLTRL apoB100LDLTRLLDLapoBapoB90%apoBLDLSniderman1TGapoB(sLDL)CHDapoBTGCHDLDLLDL-C(TC) CHDSniderman1apoBCHDapoBLDL-CTGCHD7 LDLLDLLDL-CapoBapoBLDLLDL-CLDLsLDLLDL-CapoBTGLDLapoBapoBLDL-CFriedewaldapoBapoBapoBLDL-CapoB LDL LDL()68 LDL(oxLDL) oxLDL oxLDLLp(a)oxLDL?9oxLDLLDL LDL(-)CuFeoxLDLLDL(B/E)CuLDL LDL10LDL50% LDL(MDA4HNE)LDL7-77562511LDL(-)CuapoBapoBapoB()(MDA)AsMDA-LDLAsLDLoxLDLLDLoxLDL !-empirenews.page-LDL LDLLDLLDLLDL(mm-LDL)LDLLDL LDLCuLDL123 LDLLDL9Fc(Fc rR-B2B(CD36SRB1)A(SRASRA)oxLDLFcoxLDL oxLDLAs91012 mm-LDL(MCP-1)(M-CSF)M-CSF mm-LDLoxLDLoxLDL(IL-1b)oxLDL(EDRF)(NO)LDLoxLDLNO13 LDL mm-LDL(PAI-1) oxLDL LDLDevarej10 (234 nm)LDLoxLDL()SOSapoBoxLDLoxLDLoxLDL oxLDLLDL14LDL15oxLDL Lp(a)As Lp(a)Lp(a)Lp(a)As1617(1)Asapo(a)(2)apo(a)LDLapo(a)KringleapoBapo(a)As18(3)Lp(a)(TGF)LDL(4)Lp(a)()Lp(a)apoBapo(a)LDLLp(a) !-empirenews.page-PLp(a)Lp(a)CHDLp(a)LDL(1)Lp(a)CHD/LDL-CLp(a)50 mg/L300 mg/LCHD(Odds Ratio, OR)1.7LDL-COR6.0CHDLDL-C3.48.2 mmol/LLp(a)100 mg/L 300 mg/LOR1.016.6Lp(a)LDL-CTCCHDLp(a)TCLp(a)CHD()(2)2.5AsLp(a)LDL(10%)Lp(a)(r=0.45,P0.01),LDL-CLp(a)(r=0.05)Lp(a)LDL-CCHD40%LDL-CLp(a)10%(P0.05)()(LDL-apheresis)LDL-CLDL-CLp(a)2AsCHDLDL-CLp(a)LDL-CLp(a) Lp(a)LDL-CCHD() Lp(a)19Lp(a)IFCCLp(a)1995(1)(2)(3)E