[医药]磷酸肌酸钠论文：磷酸肌酸钠治疗肺炎心衰患儿血浆BNP的变化及其对预后的指导意义.doc

磷酸肌酸钠论文：磷酸肌酸钠治疗肺炎心衰患儿血浆BNP的变化及其对预后的指导意义【中文摘要】观察肺炎心衰患儿应用磷酸肌酸钠后血浆脑钠肽(BNP)的变化以及心功能、临床症状改善情况,探讨磷酸肌酸钠在儿科心衰治疗中的应用价值以及血浆脑钠肽(BNP)的变化对心衰患儿预后的指导意义。方法：选取肺炎心衰患儿87例作为入选对象。其中肺炎心衰组患儿44例,随机分为磷酸肌酸钠CP组22例和1,6二磷酸果糖FDP组22例；先天性心脏病CHD合并肺炎心衰的患儿43例,随机分为磷酸肌酸钠CP组22例和1,6二磷酸果糖FDP组21例,入院后24小时内抽取静脉血检测血浆BNP,进行床旁胸部X线检查,心脏彩超检查测量心功能EF、FS值,同时选择同期健康小儿20例检测血浆BNP,测量心功能EF、FS值作为比较。在给予常规治疗外,分别给予磷酸肌酸钠CP0.5qd ivdrip,1,6二磷酸果糖200mg/kg.qdivdrip治疗,7天后再次抽血检测血浆脑钠肽(BNP)的浓度,测量心功能EF、FS值；观察治疗前后血浆脑钠肽(BNP)、心脏超声心功能EF、FS值的变化；观察72小时临床症状改善情况及预后评估。结果：治疗72小时临床疗效比较,磷酸肌酸钠CP组较1,6二磷酸果糖FDP有更加明显的疗效,P0.05。BNP先心病合并肺炎组中CP组T=5.2322,P0.05。结果表明BNP、EF、FS均有改善,但应用磷酸肌酸钠治疗的CP组患儿BNP、EF、FS较应用1,6二磷酸果糖治疗的FDP组患儿改善明显。BNP水平与心衰患儿的预后有关。结论：BNP水平与心衰患儿的预后有关,磷酸肌酸钠对改善心脏功能有明显疗效。【英文摘要】s:To observe the variation of plasma BNP (brain natriuretic peptide)in infants with Pneumonia combining Heart Failure and the improvement of cardiac function and clinical symptoms after Creatinephosphate Sodium treating, to explore the application value of Creatinephosphate Sodium in pediatric heart failure and the prognosis guiding significance of plasma BNP variation.Methods:87 cases infants with Pneumonia combining Heart Failure were enrolled.44 cases common Pneumonia combining Heart Failure infants were randomly divided into CP group 22 cases and FDP group 22 cases; 43 cases CHD and Pneumonia combining Heart Failure infants were randomly divided into CP group 22 cases and FDP group 21 cases. Within 24 hours after admission, drawed vein blood to test plasma BNP, detected bed side chest X-ray and echocardiography to measure cardiac EF、FS.In the meantime, choosed 20 cases healthy infants as comparation. After 7 days treated, observed the variation of plasma BNP and the variation of cardiac EF、FS value, to observe the improvement of clinical symptoms after 72 hours, to evaluate the prognosis.Results:After 72 hours treating, compared the clinical effect that the CP group is more apparent than FDP group (P0. 05. BNP in CP group of pneumonia combining Heart Failure T=5.2322, P0.005. It is turned out that the BNP, EF, FS of all enrolled infants were improved, but the CP group were more improved significantly.Conclusions:BNP levels are relate with the prognosis of infants. Treated with Creatinephosphate Sodium have apparent curative effect at the improvement of cardiac function【关键词】磷酸肌酸钠 心力衰竭 BNP【英文关键词】Creatinephosphate Sodium Heart Failure BNP(brain natriuretic peptide)【目录】磷酸肌酸钠治疗肺炎心衰患儿血浆BNP的变化及其对预后的指导意