MOFs金属有机框架结构.pptx

Metal-organic Frameworks for antibacterial activity,Chemistry Graduate Study Forum Feb 12th, 2014,Advisors,Presentation Outline,Brief Introduction and Background Experimental Procedures: MOFs Fabrication MOFs Characterization Antibacterial activity analysis Results and Discussion Conclusions Acknowledgement References,Brief Introduction and Background,formed by the self-assembly of metal ions or and poly-dentate bridging ligands; Porous crystalline materials in 1, 2, 3 dimensional structures; Most of 3D MOFs share a common cubic topology; The synthesis is frequently performed by solvothermal method; Designing modification according to various applications (like gas storage, separation, catalysis, bactericide, semiconductor),Brief Introduction and Background(Cont),Applications: gas storage, separation, catalysis, bactericide, semiconductor, and so forth.,Properties of metal-organic frameworks,Tunable surface functional groups and adjustable metal coordination environments; Porous structure with large surface area; Magnetic properties according to high or low-spin metal center, leading to different forms of magnetism. paramagnetism, Diamagnetism, Ferromagnetism, Antiferromagnetism.,Classification of MOFs,According to the degree of extension of MOFs, they are classified as 1D-, 2D-, 3D-. (Form left to right),A single chain from the Kube group,A MOF-5 sheet from the Yaghi group,A spatial structure from the Robson group,Preparation of MOFs,The most common one is called as hydro-solvothermal Method,Condition: The reaction temperature was controlled at 80C-100C and maintained for 72 hrs.,Characterization of MOFs,SEM: based on scattered electrons, mainly focus on the samples surface, composition and morphology, and provides a 3-dimensional image . TEM: based on transmitted electrons, mainly focus on the details about internal composition, like crystallization, stress or even magnetic domains, and provides a 2-dimensional picture. EDS (a analysis tool of SEM): mainly focus on elemental analysis in your composition, microstructures and thickness. X-rays: chemical composition. Antibacterial test,Results and Discussion: Crystal Structure,Eg: CPPs(coordination polymer particle),(a-c)SEM images of layer morphology and (d)3D crystal structure,(a-c) TEM images of disk morphology and (d)2D crystal structure,Results and Discussion (Cont.),X-Ray: The bulk crystals are isostructural, composed of Cu, C, and O. and the atomic ratios for C:N are all near 5:1.,Results and Discussion(Cont.),Eg: Antibacterial test against Escherichia coli (E. coli) for Co-MOFs,Experiment section: 1. The stock solution of the synthesized samples and control group were prepared in DMSO. 2. 100L MOFs, 100L microorganism with certain concentration, 1300 L nutrient solution were added and mixed. 3. After incubation at 37 for 10min, 2h, 4h, 6h, and 55 h, respectively, 4. Determine the OD with UV.,Conclusion: It shows antibacterial activities at certain concentration.,Conclusion,Mofs, as the most important families of porous materials with large surface area, has been exploited in many applications. The central metal acts as active site to inactivate the bacterial, the ability based on concentration of MOFs.,Acknowledgement,The technical support from the Chemistry Department and the Graduate scholarships are duly acknowledged for financial support.,References,1 J. L. C. Rowsell and O. M. Yaghi, Angew. Chem. Int. Ed. 2005, 44, 4670. 2 D. Sun, S. Ma, Y. Ke, D. J. Collins, and H. C. Zhou, J. AM. CHEM. SOC. 2006, 128, 3896. 3 J.Y. Lee, O. K. Farha, J. Roberts, K. A. Scheidt, S. T. Nguyena and J. T. Hupp, Chem. Soc. Rev., 2009,38, 1450 4 J. D. Rocca, D. Liu, and W. Lin, Accounts of chemical research, xxxx, xx, xxxx 5 K. Wang,