控制昼夜节律的分子机制ppt课件.ppt

First,twoquestions.,Whendoyougetup?Whendoyougotobed?,1,Thebiologicalclockiswarningyou,Themolecularmechanismofcontrollingcircadianrhythm控制昼夜节律的分子机制,Reporter：ZhangQing2018.06.06,2,Thesunsetbuttherest.（日落而息）,Thesunrisemakes.(日出而作),Aphenomenonofthecircadianrhythm/thebiologicalclock,3,HOWDOESITWORKINGENE?,4,Thefruitfly:sleepsduringthedayhowlsduringthenight,WHY?,Themutation(缺失)ofaperiodgeneinthebody,周期基因,5,HowtoRealizeRegulationofCircadianRhythmprecisly?如何实现昼夜节律的精确调控?,WhatIsthePeriodGene?,6,TheperiodgeneencodesaproteincalledPER.ThetimelessgeneencodesaproteincalledTIM.Thedouble-timegeneencodesaproteincalledDBT.,7,ThePERproteinwillbetransferredfromthecytoplasm(细胞质)tothenucleuswiththehelpofTIMproteinatnight.ThePERproteinwilldegrade（降解）duringtheday.Theprocessofaccumulationanddegradationisabout24hours,whichcorrespondstopeoplesdayandnight.DBTistoslowdowntheaccumulation（积累）ofPERprotein,whichallowspreciseregulationofcircadianrhythms.,8,Openthelockrequirestwokeys,onecalledthePERproteinandtheothercalledaTIM.Thefrequency(频率)ofopeningthedooriscontrolledbytheDBTprotein.,Theprocessislikedasalockandakey,9,First,healsomeofthegeneticdiseases（遗传性疾病）.Second,cureinsomnia(失眠).Third,revealthedangerofstayinguplate.,WhatisTheUseofThisFinding?,10,Atlastbutnotatleast,wemustletthebodyrestattherighttime