自身免疫性疾病2015英五班.ppt

AutoimmunityandAutoimmuneDiseases,GuangjieChenDept.ofImmunologyandMicrobiology2015,AutoimmunityisdefinedasanacquiredimmunereactivityagainstselfantigensThenormalphysiologicalactivityessence-autoimmuneresponseLowaffinityIgM-CD5+B1-“natural”Abspectrum,AutoimmunediseasesoccurwhenautoimmuneresponsesleadtotissuedamageThepathologicalactivityessence-autoimmuneresponseImmunologicaltolerancefailstoeliminateorcontrolpathogenicself-reactivelymphocytes,Breakingofself-tolerance,Ehrlichs“Horrorautotoxicus”,I.ThefeaturesandclassificationofAID,1.Features,2.ClassificationOrganspecificNonorganspecific,II.ThepathologicalmechanismofAID,1.autoantibodybindingtocellmembrane2.autoantibodybindingtomembranereceptor3.autoantibodybindingtoextracellularcomponents4.Theeffectofimmunecomplexdeposition5.TheeffectofautoreactiveTcell,TypeIIhypersensitivity（autoantibody)Theeffectofautoantibodybindingtocellmembrane（IgM、IgG）AutoimmunehemolyticanemiathrombocytopenicpurpuraHemolyticdiseaseofthenewborninducedbyRhesusincompatibility,TheeffectofautoantibodytomembranereceptorMyastheniagravisGravesdisease,Figure13-29part1of2,3.TheeffectofautoantibodytoextracellularcomponentsGoodpasturessyndrome,*antibasementmembrane（kidney,lung）typeIVcollagenAb,4.Theeffectofimmunecomplexdeposition*TypeIIIhypersensitivity,(1)SLE,（2）RA,(2)RA,5.TheeffectofautoreactiveTcell*TypeIVhypersensitivity,Multiplesclerosis(MS）Th1、Tc、MBPTypeIdiabetesmellitusTccell,III.PathogenicfactorsrelatedtoAID,Antigen-relatedfactorsReleasingofsequesteredantigen,AlterationofselfantigenpropertiesMolecularmimicrycommonantigencrossreactionstreptococcuskidney,heartEpitopespreading,2.AbnormalitiesofimmuneregulationFailureofself-tolerance,AbulK.abbasetal.CellularandMolecularImmunology,7thedition,ElsevierSaunders,Brokencentralandperipheraltolerance,AbulK.abbasetal.CellularandMolecularImmunology,7thedition,ElsevierSaunders,AbnormalexpressionofFas/FasL,PolyclonalactivationofTandBcells,AbulK.abbasetal.CellularandMolecularImmunology,7thedition,ElsevierSaunders,DysfunctionofTreg,AbnormalexpressionofMHC-II,3.GeneticfactorsAssociationofHLAwithautoimmunedisease,OthergenesC1q,C4genedeficiency：SLEDNasedeficiency：SLEmutantCTLA-4：Diabetes4.OtherfactorsGenderAgeEnvironmentfactor,IV.Immunologicalcontrolstrategies,Deletionfactorswhichinduceabnormalself-toleranceInhibitionofimmuneresponsetoautoAgRebuildingself-toleranceControlofinfectionAdministrationofimmunosuppressivedrugAntibodiesautoAg,ArchivumImmunologiaeetTherapiaeExperimentalis(AITE),2010,58：27-36,ArchivumImmunologiaeetTherapiaeExperimen