头孢菌素等抗菌药物皮肤过敏试验皮试液配制方法.doc

头孢菌素等抗菌药物皮肤过敏试验皮试液配制方法头孢菌素等抗菌药物皮肤过敏试验皮试液配制方法 中国药典-临床用药须知（2005版）规定：使用青霉素类抗生素前均需做青霉素皮肤过敏试验，阳性反应者禁用。对头孢菌素类抗生素未明确规定必须做过敏试验，但有过敏史或过敏体质者等，可根据情况用原药做皮肤过敏试验。 类别通用名商品名（或别名）皮试液配制方法皮试液浓度试敏时取皮试液量取药量加入生理盐水的量第一次第二次至第三次至第四次至第一代头孢菌素头孢唑啉先锋号1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml头孢硫脒仙力素1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml头孢替唑特子社复1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml第二代头孢菌素头孢呋辛达力欣1.0g5ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.85ml余0.15ml1ml300g/ml0.1ml丽扶欣1.5g12ml抽取0.4ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml头孢西丁海西丁1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml头孢替安替他欣0.5g5ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.7ml余0.3ml1ml300g/ml0.1ml佩罗欣1.0g5ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.85ml余0.15ml1ml300g/ml0.02ml类别通用名商品名（或别名）皮试液配制方法皮试液浓度试敏时取皮试液量取药量加入生理盐水的量第一次第二次至第三次至第四次至第三代头孢菌素头孢唑肟益左欣0.5g2ml抽取0.2ml1ml推掉0.9ml余0.1ml1m推掉0.9ml余0.1ml1ml500g/ml0.1ml头孢他啶头孢他啶0.5g2ml抽取0.2ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml新天欣0.75g5ml抽取0.1ml1ml推掉0.8ml余0.2ml1ml推掉0.9ml余0.1ml0.6ml500g/ml0.1ml益他欣1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml凯复定1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1m推掉0.9ml余0.1ml1ml500g/ml0.1ml头孢米诺立健诺1.0g2ml抽取0.1m1ml推掉0.9ml余0.1ml1m推掉0.9ml余0.1ml1ml500g/ml0.1ml头孢匹胺先锋利胺1.0g5ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.85ml余0.15ml1ml300g/ml0.1ml头孢曲松罗氏芬1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1m推掉0.9ml余0.1ml1ml500g/ml0.1ml第四代头孢菌素头孢吡肟马斯平1.0g10ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.7ml余0.3ml1ml300g/ml0.1ml氟氧头孢氟吗宁1.0g4ml抽取0.1ml10ml推掉9ml余1ml8ml_300g/ml0.02ml-内酰胺酶抑制剂头孢哌酮/舒巴坦先普0.5g4ml抽取0.4ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml铃兰欣1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml舒普深1.0g2ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml新瑞普欣1.5g20ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml可倍2.0g4ml抽取0.1ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml500g/ml0.1ml碳青霉烯类帕尼培南/倍他米隆克倍宁0.5g2.5ml抽取0.15ml1ml推掉0.9ml余0.1ml1ml推掉0.9ml余0.1ml1ml300g/ml0.02ml阳性结果判断标准：皮试液注射20分钟后判断。1、皮试液为0.1ml者：局部出现红肿，直径大于1cm或局部红晕或伴有小水泡2、皮试液为0.02ml者：有下列情况之一红晕直径在20mm以上丘疹直径在9mm以上丘疹周围伴有伪足时注射局部虽然为阴性，但有全身反应（麻木、发热、头痛、眩晕、耳鸣、不安、脉速、不快感、口感异常、便意、出汗等）情况时有关说明：头孢西丁从药理学角度进行分类应为头霉素类而非头孢菌素类，但其抗菌谱及其抗菌强度与第二代头孢菌素相似，故将其归入第二代头孢菌素。同理，将头孢米诺归入第三代头孢菌素；氟氧头孢归入第四代头孢菌素。附件中的试敏方法只有头孢替安（佩罗欣）皮试液用量改为0.02ml，判断标准也相应改变。其他药物与以前相同。 刘高峰2.我院青霉素类抗菌药物皮内试验试敏液配制方法按我国卫生部规定，使用青霉素类抗生素前均需做皮肤试验，阳性反应者禁用。（2005版中华人民共和国药典-临床用药须知以下简称临床用药须知）青霉素类不同品种间存在着交叉过敏关系。青霉素类药物在应用前可用青霉素G钠皮试液进行皮试。（第15版新编药物学）按临床用药须知（2005版）规定，青霉素皮肤试验溶液配制方法如下：同时临床用药须知还规定，做青霉素皮试时须注意：1. 极少数高敏患者可在皮肤试验时发生过敏性休克，常于注射后数秒至5分钟出现，应立即按过敏性休克抢救方法进行救治；2. 试验用药含量要准确，配制后在冰箱中保存不应超过24小时；3. 更换同类药物或不同批号或停药3天以上，须重新作皮内试验。 通用名皮内试敏液配制方法皮试液浓度皮内注射时取皮试液量取药量加入生理盐水的量第一次第二次至第三次至第四次至注射用青