肝癌细胞凋亡调控的研究进展.doc

hepatocellular carcinoma, hcc hcc , p53, bcl-2, survivincaspasetrail cox-2 ; p53; survivin; caspase; trail; cox-2hepatocellularcarcinoma, hcc , hcc, , , p53fasbcl-2/bax 1. , , bcl-2survivin, p53fas/fasltrail, 11 p53 p53 , p5320kb, 17q13.1,11, , dnap53, p53p53, p53p53, ,p53hcc69.3718.81%, , 3, p53 , bcl-2bax12 fas fas/fasl,fasfasl sfassfaslfas,n80, fas, fassfas, fas, , faslfasfascaspase-8 fasl9,1011fashcc, ,fashcc, fashcc fas/fasl,hcc fas, sfasfasl, fas/faslhccfasfasl, fas/fasl12, hccfaslfas, , fas, fas-1flipflice/caspase-8inhibitoryproteinfas, fasbcl-2p53fas13bcl-2cytokinbcl-2baxadriamycin hcc-92041814 survivin survivininhibitor of apoptosis protein, iapiapiapbaculovirus iap repeatsurvivin17q25,43,2510319survivin survivin ikeguchi2057hcc,41%survivin mrna,survivinsurvivinsurvivin, survivinsurvivin,survivinbircaspase-3caspase-7, survivinc, caspase-9, 19,27gaoyan21survivin-sirna,sirna, rnaisurvivinhepg2, 22 survivin sirna survivin mrna , survivin survivin , survivinchen23, smmc-7721 caspase-3,survivin asodn , caspase-3 , smmc-7721 caspase-3 survivin asodn survivincaspase-3, cheng24rnaismmc-7721 survivinsurvivinsurvivin2. caspasetgf/tgf, tnf, cox-22.1. caspase caspase-3, 25tnf-tnfr, faslfasddfaddfaddcaspase-8deddisccaspase-8bidccaspase-3caspasecaspase-3dnapoly adp-ribose polymerase parpparpdna 26fascaspase-3caspase-3devdchocaspase-3fasiceyvadchofasfascaspase-3iceabcl-7402ccaspase-317nk-104hmg-coa10 mol/l nk-104caspase-3mevnk-104 27caspasecaspase-328 -gsh-dxrdxrah66caspase-31001215hcaspase-3dna29caspase-3dnabaxatpc cyt c atp -1apoptotic protease-activating factor1apaf-1 cyt c cyt capaf-1 procaspase-9 apoptosome caspase-9 caspase-9 caspasecaspase-9 caspase-9 caspase-930 cyt c capocytochrome c diekert 31apocytochrome c tom tom apocytochrome c as2o3 tom20caspase-3 caspase-9 caspase-3 caspase-92.2. tumornecrosisfactor-related apoptosis-inducing ligand, trailtrailtumornecrosisfamily, tnf, tnf, , caspase, trail, trail, hcctrail32trailnf-b, nf-bsn50 trail hcc, trail, trailnf-btrailhcc hcctrail, cfilpcaspase8/fliceinhibitory protein, cfilpbcl-xlbaxbid33 trailbcl-2, bcl-xlbaxtrailnf-btrail