安素泰说明书.doc

:1: 2: 1100mg/m23462 15% 250100mg53cap 75mg/m25%800mg500ml75mg/m2500ml1500ml242000ml 5-10mg 21 22cav nse 1 5%5002 8mg400mg 3 600mg0.9%50044 8mg400mg 5 405%250 6 5%27 8 1 5%5002 8mg400mg 3 600mg0.9%5004 4 8mg400mg 5 5%26 8 nsense29ce 500mg5%500ml4368mgvp16100mg500ml4368mg 22 22-27 nc 19mg100ml40mg50ml5mg100ml50ml1050ml 29mg100ml500mg5%500ml4 21 822 22 2329 * * 20% pc 2240.75mg209100210mg500ml4103b3020mg40mg9100500mg5%500ml4 32 * * * * 30250pi nse 60mg/m2100ml60mg/m2500ml1500ml242000ml5-10mg 1560mg/m2100ml29 16%nsense29tp 2240.75mg27210mg500ml43b3020mg40mg368mg 50mg5%500ml4368mg20mg5%250ml15002000ml 32 212225 * * * * * * 30250 10.75mg61 75mg/m2500ml33b5005%50051002 91001.8g100ml30 50mg5%500ml436920mg5%250ml15002000ml 91001.8g100ml302244 400ug21 b12 1000ugb124mg500mg/m2100ml10 75mg/m25%500ml452000ml 13100 22.0g100ml30 35004310022(tax)paclitaxelanzataxpaclitaxelumptxtaxol(6)1. (taxus brevis)/(gtp)(map)2. (cmax)435-802ng/ml6-12(85ng/ml)89%-98%0.276.4(13%)1. (1)(2)(3)1.510e9/l(4)110e9/l(kaposis)()2. (1)(2)()(3)()3. 1. 112. 62%4%()3. 30%4. 55%2-3(g-csf)5. 8%23%18%6. 100%7. 8. 9. (2%)-1. /p450 3a42. 1.53. 1/34. 2448()5. 6. 7. p450 3a41. 2. 12620mg30-60()50mg300mg(50mg)3. 0.3-1.2mg/ml5%5%4. 0.22m5. 1%6. 11517. 1.510e9/l10010e9/l(0.510e9/l1)20%8. () 135-175mg/m2331150mg/m22-33-41. (1)6175mg/m2331(2)175mg/m233142. kaposis(1)135mg/m2331(2)100mg/m2321(3)10mg(20mg)(g-csf)3. 135mg/m22475mg/m2314. (1)135mg/m224175mg/m2375mg/m231(2)135mg/m2175mg/m2331 1. 101/100,0001/10,0001/10001/1001/10151ml2ml4ml8ml1ml1532. 20mg61413050mg301-22410%-25%3-624 5ml:30mg2-8 nsclcnsclc80%bnsclccddpcbpbnsclcnsclc 1 pc1. txl135175215225mg/m 2. txl3 1260.75mg26210mg500ml430400mg40mg50mg5%500ml420mg5%250ml15002000ml232 212225 * * * * * * 302502 gp21cddp gemdnansclcgemcddpbnsclc40.6% 3 vp1. vn