抗抑郁药物及其研究方法的进展_杨小莹 (1)（antidepressants and research methods in _ yang xiaoying (1)）

抗抑郁药物及其研究方法的进展_杨小莹1（ANTIDEPRESSANTSANDRESEARCHMETHODSIN_YANGXIAOYING1）36YATIMAHALIAS，KHALIJAHAWANG，AHAMIDAHAD，我一个一个埃塔TIMITOTIC和细胞毒性FROMFISSISTIGMALANUGINOSUM查尔酮J。JNATPROD，1995,581160。37NICHOLASJLAWRENCE，DAVIDRENNISON，ALANTMCGOWN，等一等一个橙酮的全合成FROMUVARIA源分离噢，黄酮类化合物作为抗癌剂的研究J。BIOORGMED化学其中，2003,133759。38NORIYOSHINAKATAN，MOMOYOICHIMARU，MASATAKAMORIYASU，等对人早幼粒细胞白血病细胞凋亡诱导L粒BYC苄查尔酮类，UVARETIN，ISOUVARE锡和双紫玉盘素J。BIOLPHARMBUL，2005,2883。39WUJH，WANGXH，YIYH，我再AGENTS54IAIDS埃塔。一个宝帐篷蚂蚁纵横混排查尔酮和黄酮的GENUSDESMOSJ。BIOORGMED化学快报，2003,131813。40PHANVANKIEM，CHAUVANMINH，HOANGTHANHHUONG，等一等AGAINSTNFATTRAN有抑制活性的酚类成分描述FROMDESMOSCHINENSISJ。拱医药研究，2005,281345。41MAYUNGAHHNKUNYA，HUGOWEENEN，DOROTHYHBRAY，等一等坦桑尼亚植物及其活性成分的抗疟活性学生紫玉盘属的研究J。PLANTAMED，1991,57341。42SHOKOYOKOYAMA，TADAHIROTAKEDA，HIROMITAKAHASH，我等一等脂质过氧化与抗氧化作用3，5,7,4四羟基黄酮；原子FORCEMI直接观察研究J。JOLEOSC，我2002,5163。在从番荔枝科和生物黄酮类化合物的研究进展这些化合物的活性胡CHUNMEI1，2、五JIUHONG2（1。药理学与毒理学研究所，中国科学院OFMILITARYMEDICAL，BEIJING100850；2。药剂科，306HOSPITAL有限，北京100101，中国）摘要超过50个新的黄酮类化合物来自ANNONACEAE的报道在过去的二十年。在许多属NONACEAE包含有STRUCTURALNOVELTY和广泛的药理活性的黄酮类化合物。由于一些药理利益在这些化合物中，关于这个问题的化学研究在几十年中有了长足的发展。这里的生物活性部分这些黄酮类化合物也进行了简要讨论。关键词番荔枝科；黄酮类化合物；生物活性；ANTI肿瘤责任编辑戴畅收稿日期20061210基金项目江苏省自然科学基金项目（BK2005149）；江苏省中医药局中医药科研项目（H05074）；江苏省教育厅自然科学基金项目（02KJB360002）通讯作者马世平，TEL（025）85322594，邮件我SHIPINGMAHOTMAILCOM。抗抑郁药物及其研究方法的进展杨小莹1，陈杰2，YANGXINMING2,MASHIPING11、DEPARTMENTOFPHARMACOLOGY,CHINESEMATERIAMEDICA,CHINAMEDICINEUNIVERSITY,JIANGSU210038,NANJING,CHINATHEQUALITYDEPARTMENT2GUANGDONGBIDIPHARMACEUTICALCOLTD,GUANGDONGKAIPING529331ABSTRACTTHEPREVENTIONANDTREATMENTOFDEPRESSIONHASATTRACTEDWORLDWIDEATTENTIONTHROUGHCONSULTINGRELEVANTLITERATURESATHOMEANDABROADINRECENTYEARSANDCOMBININGRELEVANTRESEARCHRESULTS,THETHECLASSIFICATIONOFANTIDEPRESSANTDRUGS,ESPECIALLYTHEEXTRACTSOFNATURALDRUGS,ACTIVEINGREDIENTSANDCHINESEHERBALMEDICINE,ISREVIEWEDANDREVIEWEDTHEPROGRESSOFTHEEXPERIMENTALMETHODANIMALMODELISSUMMARIZED,ANDTHECONSISTENCY,INADEQUACYANDCLINICALVALUEOFTHEEXPERIMENTALRESEARCHMETHODSCOMBINEDWITHCLINICALPRACTICEARESUMMARIZED770THIRTYSECONDVOLUME,NINTHISSUEINMAY2007,CHINESEJOURNALOFTRADITIONALCHINESEMEDICINE,CHINA,JOURNAL,OFCHINESEM,ATERIAM,EDICA,VOL32,ISSUE,9MAY,2007ANDOTHERASPECTSWEREANALYZEDANDDISCUSSEDDEPRESSIONNATURALDRUGSANIMALMODELSCLINICALEFFECTSCLCNOR2855DOCUMENTIDENTIFICATIONCODEAARTICLENUMBER10015302200709077005DEPRESSIONDEPRESSIONISCAUSEDBYAVARIETYOFCAUSESANDISCHARACTERIZEDBYMOODDISORDERSMAJORFEATURESOFTHESYNDROMEWITHTHEINTENSIFICATIONOFALLKINDSOFSTRESSFACTORS,THEINCIDENCEISPOSITIVEINTHERAPIDRISE,HIGHINCIDENCEANDDIFFICULTTOCUREBUTITSPATHOGENESISISVERYCOMPLEX,SOFARITHASNOTBEENELUCIDATEDFROMTHEEARLIESTMONOAMINEHYPOTHESISTOTHEHYPOTHALAMUSPITUITARYADRENALGLANDHPAAXISNEGATIVEFEEDBACKDYSREGULATION,ANDTHENCELLULARANDMOLECULARMECHANISMS,MAYBEASSOCIATEDWITHDEPRESSIONMORBIDITYRELATEDASTHEPATHOGENESISISRAISED,THEETIOLOGYOFDEPRESSIONISCLARIFIEDFURTHERENRICHTHEEXPERIMENTALRESEARCHMETHODS,BUTALSOFORTHEDEVELOPMENTOFSAFEANDEFFECTIVENEWDRUGSREFERTOCLEARDIRECTIONINRECENTYEARS,ESPECIALLYTHESTUDYOFANTIDEPRESSANTNATURALDRUGSHASMADEONEDEFINITEDEVELOPMENTPROVIDESAWIDERANGEOFDRUGSWITHHIGHEFFICACYANDLOWSIDEEFFECTSFOREGROUNDTHEAUTHORREVIEWEDTHEDOMESTICANDFOREIGNANTIDEPRESSANTDRUGSINRECENT5YEARSTHERESEARCHPROGRESSANDTHEPROGRESSOFRELATEDRESEARCHMETHODSARESUMMARIZED1ADVANCESINANTIDEPRESSANTDRUGSITSDEVELOPMENTANDDEVELOPMENTISANEWBREAKTHROUGHINTHETREATMENTOFDEPRESSION,ESPECIALLYNATURALDRUGSTHERESEARCHWILLBECOMETHENEWHOTSPOTANDTHEDEVELOPMENTTENDENCY11CHEMICALANTIDEPRESSANTNEWANTIDEPRESSANTDRUGSDEVELOPEDINRECENTYEARSINCLUDEBOTHDOPAMINEDAANDD2ARECEPTORFORPARTIALAGONISTAND5SEROTONIN1A5HT1ARECEPTORAGONISTACTIONINANIMALMODELTESTS,BIFEPRUNOXHASAGOODANTIDEPRESSANTEFFECTPHASEIIICLINICALSTUDYWASPERFORMED,1CORTICOTROPINRELEASINGHORMONECRHRECEPTORANTAGONISTANTALARMINCANREVERSETHEHPAAXISCHANGESINDUCEDBYCHRONICSTRESSTHECURATIVEEFFECTISEQUIVALENTTOTHATOFFLUOXETINE,2MELATONINRECEPTORAGONISTSAGOMELATINEAGOMELATINEFIRSTANTIDEPRESSANTTARGETSTARGETINGMELATONINHORMONERECEPTORSDRUGSAREAGONISTSOFTHEMELATONINRECEPTOR1ANDRECEPTOR2,AND5HT2CRECEPTORANTAGONISTS,THEEFFICACYOFTHISDRUG,ISCOMPARABLETOTHECURRENTLYUSEDSELECTIVESEROTONIN5INHIBITORSSSRISANDNOREPINEPHRINEREUPTAKEINHIBITORSSNRISPHASENEAR,BUTRARELY,THETYPICALADVERSEREACTIONSOFTHETWOPATIENTSWEREWELLTOLERATEDATPRESENT,SERVIERHASSUBMITTEDANAPPLICATIONFORREGISTRATIONOFTHEDRUGINTHEEUROPEANUNIONFORTREATMENTTREATADULTSWITHDEPRESSION,3,4ACCORDINGTOREPORTS,THEUNITEDSTATESSYNAPTICPHARMACEUTICALCOMPANYFOUND1NEW,POWERFULANTIDEPRESSANTWITHTARGETSOF1GPROTEINCOUPLEDRECEPTORSTHEANTIDEPRESSANTEFFECTISSIMILARTOTHATOFPROZAC,ANANTIDEPRESSANT,FLUOXETINE,ANDISNOTFEWGOODREACTIONS12ANTIDEPRESSANTNATURALDRUGS121ANTIDEPRESSANTCOMPONENT1211NOLDNER5RUTINOFFLAVONOIDSRUTINISHYPERICUMPERFORATUMANTIDEPRESSANTACTIVEINGREDIENTSLIYUNFENGAND6REPORTEDTOTALFLAVONOIDSOFCOTTONSEEDCTN1TOSHORTENTHEIMMOBILITYTIMEOFFORCEDSWIMMINGFSTANDTAILSUSPENSIONTSTINMICEANDMICE,SEROTONINACID5HTPENHANCED5INDUCEDHEADTWITCHESZHANGLIMING,ETAL,71NOVELANTIDEPRESSANTS,QUERCETIN,3O,APIGENIN,RUTINGLYCOSIDESCTN986THEEFFECTO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