![[生物医药论文精品a]冰片作用下替莫唑胺在家兔体内的药代动力学研究_第1页](http://file.renrendoc.com/FileRoot1/2017-12/8/250cba2f-0ac5-4b68-b274-10751b5736e0/250cba2f-0ac5-4b68-b274-10751b5736e01.gif)
![[生物医药论文精品a]冰片作用下替莫唑胺在家兔体内的药代动力学研究_第2页](http://file.renrendoc.com/FileRoot1/2017-12/8/250cba2f-0ac5-4b68-b274-10751b5736e0/250cba2f-0ac5-4b68-b274-10751b5736e02.gif)
![[生物医药论文精品a]冰片作用下替莫唑胺在家兔体内的药代动力学研究_第3页](http://file.renrendoc.com/FileRoot1/2017-12/8/250cba2f-0ac5-4b68-b274-10751b5736e0/250cba2f-0ac5-4b68-b274-10751b5736e03.gif)
![[生物医药论文精品a]冰片作用下替莫唑胺在家兔体内的药代动力学研究_第4页](http://file.renrendoc.com/FileRoot1/2017-12/8/250cba2f-0ac5-4b68-b274-10751b5736e0/250cba2f-0ac5-4b68-b274-10751b5736e04.gif)
![[生物医药论文精品a]冰片作用下替莫唑胺在家兔体内的药代动力学研究_第5页](http://file.renrendoc.com/FileRoot1/2017-12/8/250cba2f-0ac5-4b68-b274-10751b5736e0/250cba2f-0ac5-4b68-b274-10751b5736e05.gif)
已阅读5页，还剩4页未读， 继续免费阅读
版权说明：本文档由用户提供并上传，收益归属内容提供方，若内容存在侵权，请进行举报或认领
文档简介
1冰片作用下替莫唑胺在家兔体内的药代动力学研究李红霞，黄佳，史卫忠，赵志刚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,A181A182A183A131A58A59A60A61A172A184A108A110A170A171A68A185A186A187A188A58A59A60A61A94A53A54A94HPLCA94A108A110A170A171A94A62A189A63A190A64A191A192A83A193A194A195R9691A196A197A113A198A199A195BTHEPHARMACOKINETICSOFTEMOZOLOMIDEINRABBITSAFTERINTRAGASTRICADMINISTRATIONOFBORNEOLLIHONGXIA,HUANGJIA,SHIWEIZHONG,ZHAOZHIGANGA200DEPARTMENTOFPHARMACY,BEIJINGTIANTANHOSPITALAFFILIATEDTOCAPITALMEDICALUNIVERSITY,BEIJING100050,CHINAABSTRACTOBJECTIVETODEVELOPTHEHIGHPERFORMANCELIQUIDCHROMATOGRAPHICANALYSISOFTEMOZOLOMIDETMZINRABBITPLASMAANDCEREBROSPINALFLUIDCSFTOCOMPARETHECHANGEOFPHARMACOKINETICSOFTMZAFTERINTRAGASTRICADMINISTRATIONOFBORNEOLMETHODSWHITEA201A202A203A204A205A206A207A208A209A210A211A212A213A214A203A215A216A217A210A218A219A203A204A220A22120061D0300415A222A223A224A225A226A227A228A229,A230,A231A232A233A234A235A236A237A222A223A226A238A239A240,A241,A242A243A244A245,TEL01067022063,EMAIL1022ZZGSINACOM2RABBITSA2462505KGA247WERERANDOMLYDIVIDEDINTOCONTROLGROUPANDBORNEOLGROUPTHECONCENTRATIONSOFTMZINPLASMAANDCEREBROSPINALFLUIDWEREDETERMINEDBYHPLCWHICHINVOLVEDSELECTIONOFMETRONIDAZOLEASINTERNALSTANDARDISFOLLOWEDBYSEPARATIONONAREVERSEDPHASEC18COLUMNANDQUANTIFICATIONBYUVABSORBANCEAT329NMBLOODANDCSFSAMPLESWEREOBTAINEDAFTERINTRAGASTRICADMINISTRATIONOFTMZ12MGKG1WITH/WITHOUTBORNEOL07GKG1ATDIFFERENTTIMETHEPLASMA/CSFCONCENTRATIONTIMECURVESWEREFITTEDANDTHEPHARMACOKINETICPARAMETERSWERECALCULATEDWITH3P97PRACTICALPHARMACOKINETICPROGRAMRESULTSTHESTANDARDCURVEOFTMZWASLINEAROVERTHERANGE01A24820GML1ITSREGRESSIONEQUATIONWASPA24900723CA2506106RA24909998INPLASMAANDPA24900734CA25000054RA24909997INCSFTHEAVERAGERECOVERYOFTEMOZOLOMIDEWASMORETHAN75THEPHARMACOKINETICSOFTEMOZOLOMIDEINRABBITCOULDBERESPECTIVELYDESCRIBEDBYATWOCOMPARTMENTMODELINPLASMAANDAONECOMPARTMENTMODELINCSFTPEAK,CMAXANDAUCWEREINCREASEDINBORNEOLGROUPANDTHEPERMEABILITYOFBLOODBRAINBARRIERBBBWASINCREASEDBY1563CONCLUSIONBORNEOLCANINCREASETHEBIOAVAILABILITYOFTMZINPLASMAANDCSFTHEINCREASEOFCONCENTRATIONOFTEMOZOLOMIDEINTHECSFOFRABBITSSUGGESTSTHATBORNEOLCANIMPROVETHEPERMEABILITYOFBBBKEYWORDSTEMOZOLOMIDE,BORNEOL,HPLC,BBB,PHARMACOKINETICSA251A252A253A254A255A158R9691A160A0A1A2A3A158BA23A4A5A6BLOODBRAINBARRIER,BBBA164A165A7A8A9A10A11A12A13A4A14A15A17A66A16A4A18A19A20A21A22A24A17A176A25A26A27A28A29A30A31A32A33A34A181A29A30A182A35A36A37A38A39A40A41A42A43A44A45A46A47A48A49A50A51A52A53A54A44A55A56A57A58A43A191A192A59A60A61A196A31A62A63A197A198A64A29A65A67A68A69A70A56A57A71A72A32A73A37A74A75A76A77A197A139A78A29A30A36A37A38A39A40A31A51A79A801A81A55A82A83A84A85A86TEMOZOLOMIDEA34A206A871A88A207A89A90A91A92A31A93A94A95A54A29A30A34A93A94A210A71A96A97A98A99A100A34A147A30A101A63A46A102A34A38A39A51A79A103A104A802A81A55A216A29A71A105A106A73A37A74A75A34A217A107A37A108A109A110A54A44A111A104A34A221A112A63A223A113A54A114A115A103A116A228A117A118A119A110A55A871A82A83A84A85A231A120A1213FIG1STRUCTUREOFTEMOZOLOMIDEA122A67A68A123A32A28A180A124A73A125A126A37A127A128A40A82A83A84A85A31HPLCA129A130A131A132A34A35A133A134A84A135A136A137A32A138A129A130A34A234A140A141A142A143A102A28A144A145A103A55A146A138A107A148A67A68A56A57A62A63A210A82A83A84A85A36A73A128A126A37A127A128A40A31A45A46A149A95A34A240A150A56A57A107A180A124A151A136A82A83A84A85A29A64A152A153A154A31A155A156A551A245A157A159A161A16211A163A166A167A168A169A170A171A172A173A174A251A175A177A178A179A183A184A185A186A187A188A189A190A193A194A195060804A199A200A201A202A203A204A205A208A247A209A185A211A185A212A213A214A215A218A219A184A199A200A220A222A224A225A203A205A208A247A209A226A227A214A247A229A215A230A247A232A233A184A190A193A194100191A235200305A199A200A236A237A238A239A209A241A242A243A244A246A248A189A199A200A249A250A252A253A250A253A254A252A187A255A250A130A0A1A15A2A209A241A242A243A244A246A248A189A199A200A224A77A0A3A4A2A209FISHERA17A5A199A1812A19A6WATERS510A35A7A8A9A10A11A19A12WATERS484A21A167A13A14A6A16A20A10A11A38A158KROMASILC18A38A125MA2246MM250MMA16A20A23A51A9A158A87A24A9605A75A76A25A1220A15880A22V/VA16A20A23A26A1581MLMIN1A20A38A27A158A136A27A20A21A167A13A14A28A29A158329NMA5413A30A31A32A33A57A34A36A37A39A402505KG30A41A42A43A44A45A46A32A33A47A48A49A50A52SCXKA442002A5300005A55A56A58A59A60A61A562A30A31A62A6321A64A247A65A66A67A68A69A70A71A72A73A74A78A79A80A81A82A83A84A85A86A88A89A8516A90A91A92A93A8514A90A94A91A95A978HA98A99A100A101A102A79A103A104A91A88A89A85A105A106A88A8907GKG175A107A108A109A110A111A91A92A93A85A105A112A113A10075A107A108A109A911HA114A84A85A115A116A11720A107A118A119A120A1215A1226MLKG1A97A123A124A125A126A127A91A128A129A131A132A133A134A135A101A102A137A138A91A139A140A141A142A143A144A170A145A146A147A148A149A86A150A151A149A94A152A146A153A154A91A74A155A156A115A157A159A160A141A142A143A152A139A98A84A85A117A12812MGKG1A70A161A100A91A67A162A163A8360MGML1A70A164A165A166A168A105A106A91A82A169A171A172A173A7015MINA17430MINA17445MINA1741HA17415HA1742HA17425HA1743HA1744HA1746HA1748HA17410HA17412HA152A139A175A146A153A154A160A135A176A177A211A70A178A179A140A155A91A178A1793500RPM10MINA91A82A178A139A18010ML/A146A153A15402MLA91A181A182A183A110A154A86A184A185A166100GML1A94100L/A139A154A9120L/A146A153A154A911MOLL1HCLA186A211A86A187A186A248A64A247A70A188A189A831A1909A94A91A16020CA191A192A193A194A9822A195A196A197A198A199A200A201A202A20305MLA204A205A200A206A207A208A209A210A212A203A213A214A215A204A215A2163MLA208A217A218A219A220LMINA208A221A222A223A22410MINA208A225A2265MINA227A228A229A230A231A232A233A234A235A236A237A238A22740CA239A240A241A242A243A244A227A245A246A249A250A251200LA2414A252A253A254A255A227A79A241A0A103A227A22920LA104A1HPLCUVA228A15A54A26A2A232A158A229A64A211A26A2A23202MLA238A227A250A251A140A229A254A16A3A64A3A1315MLA227A79A241A0A103LMINA227A81A4A83A510MINA227A225A2265MINA227A228A229A230A231A232A233A234A235A236A237A238A22740CA239A240A241A242A243A244A227A245A246A249A250A251100LA241A252A253A254A255A227A79A241A0A103A227A22920LA104A1HPLCUVA228A15A5423A38A6A7A72A34A8A93A68A22A51A9A10A11A42A12A17A30A14A18A19A34A20A67A82A21A115MINA94A23A17A24A25A27A28A96A29A45A98A31A99A150A32A100A28A96A169A91A33A35A85A36A37A39A40A28A29A115758MINA41A43A31A44A46A47A173A48A49A28A50A52A53A55A272A56A57A58A31A59A60A244A61A62A40A63A28A65A66A69A702A71A73A74A75A76A77A78AA80A84A86A87A88A89A90A92A95A97A101A102A105A10610GML1A107A108BA80A84A86A87A88A89A90A109A110A105A111A112A92A95A108CA113A114A116A86A117A118A119A12007GKG1A121A109A110A105A111A122A109A110A105A111A121A87A88A123A124A108DA125A126A127A128A129A130A131A132A133A134A135A136A137A138A13910GML1A141A142EA125A126A127A128A129A130A131A132A143A144A138A145A146A133A134A142FA147A148A149A127A151A152A153A15407GKG1A155A143A144A138A145A156A143A144A138A145A155A128A129A130A157A1591A143A144A138A1452A133A134FIG2TYPICALCHROMATOGRAMSOFTEMOZOLOMIDEABLANKPLASMASPIKEDWITHISMETRONIDAZOLE,10GML1BPLASMASPIKEDWITHTEMOZOLOMIDE10GML1ANDISCPLASMAOBTAINEDFROMARABBITAFTERINTRAGASTRICADMINISTRATIONOF07GKG1TEMOZOLOMIDEDBLANKCSFSPIKEDWITHISMETRONIDAZOLE,10GML1ECSFSPIKEDWITHTEMOZOLOMIDE10GML1ANDISFCSFOBTAINEDFROMARABBITAFTERINTRAGASTRICADMINISTRATIONOF07GKG1TEMOZOLOMIDE1TEMOZOLOMIDE,2ISA160A161A162A163A164A165A166A165A167A166A165A168A166A165A170A171A166A165A170A172A166A165A165A170A171A174A167A175A172A176A168A177A170A165A170A170A178A179A180A181A178A182A182A180A179A180A181A180A182A180A182A179A183A181A184A180A180A183A179A183A181A185A185A184A186A179A187A181A188A183A187A189A190A191A192A193A194A195A194A196A195A194A197A198A195A194A199A200A195A194A201A199A195A194A194A197A199A201A200A202A198A203A196A204A197A194A197A197A205A206A207A208A205A209A210A212A206A212A208A212A213A212A213A206A213A208A210A214A215A209A206A209A208A215A213A207A210A206A216A208A214A205A207A217A218A219A220A221A222A223A224A225A223A224A225A226A224A225A227A225A224A225A227A228A224A225A227A229A224A225A225A227A223A230A228A231A226A232A229A233A227A225A227A227A234A235A236A237A234A238A236A236A235A239A237A239A240A241A242A235A240A237A236A240A243A245A246A247A248A249A250A251A252A253A251A252A253A254A252A253A255A253A252A253A255A11A252A253A255A0A252A253A253A255A251A14A11A15A254A16A0A17A255A253A255A255A1A2A3A4A5A6A7A3A2A3A4A8A3A7A9A2A6A4A6A6A10A6A2A12A4A3A5A12A13A18A19A20A21A22A23A22A24A25A23A22A26A27A23A22A25A26A23A22A28A29A23A22A22A24A26A30A25A28A29A31A27A32A24A22A24A24A33A34A35A36A37A33A38A39A34A40A36A37A33A37A41A42A43A44A45A46A47A46A48A49A47A46A50A51A47A46A52A53A47A46A49A52A47A46A46A48A51A50A52A54A49A55A53A56A48A46A48A48A57A58A59A60A61A59A62A63A58A59A60A64A57A63A61A58A63A60A57A62A63A65A58A65A60A66A63A59A64A58A62A60A66A64A61ABCDFE524A106A67A68A69A70A71A72A73A86A74A75A108A76A77A78A79A80A81A82A83A78A138A84A85A78A109A87A79A103A173A88A89A90A91A92A93A94A95A9601G/MLA92A97A247A98A99A100A101A102A199A104A105A97A107A110A100S/NA11110A112A146A11301G/MLA115A93A94A107A110A114A116A133A11725A118A119A120A121A122A123A124A125A126A127A128A129A130A131A132A134A135A136A137A139A140A14105A142A143A144A14520A15880A136V/VA147A148A149A136A150A22710MGML1A151A152A153A154A155A156A157A159A160A161A162A151A163A164A165A166A167A179A168A169A170A171A172A174200A175150A175100A17550A17525A17515A1755A1752A1751GML1A151A176A177A178A155A180A156A157A205A181A22320CA182A183A178A184A185A186A187A215A188A189A190A191A192A176A177A152A153A154A155A156100LA157A181A223A193A194A195A196A197A198A200A201A157A250A202A171A172A203A20410MLA206A207A208A209A210A157A211A212200A175150A175100A17550A17525A17515A17505A17502A17501GML1A207A208A209A210A189A190A191A192A152A153A180A156A157A213A203100GML1A151A214A216A191A180A156100LA1571MOLL1HCLA217A218A219A220A217A248A221A222A151A164A224A1741A2259A226A202A157A228A229242A230A231A232A233A234A157A235A169A170A219CA226A236A189A190A191A192/A214A216A191A237A238A239A219PTMZ/ISA226A240A241A242A243A244A245A157A244A245A246A249A174PA25100723CA2526106RA25109998A185A253A254A156A151A255A199A246A0A248A209A156A1A2A157A212A173A244A245A246A249A174A225PA25100734CA25200054RA25109997A18526A114A3A94A4A5A6A7A116A17902GML1A8A107A18A915GML1A8A29A18A915GML1A8A35A18A130A10A169A132A93A94A17A42A11A5A6A7A4A57A12A9A57A13A114A3A94A54A8NA1275A18A151A43A14A16A19A20A138A19A21A22A23A24A25A26A27A28N5TABLE1INTRADAY,INTERDAYPRECISIONANDRECOVERYOFTHEMETHODN5A30A24G/MLA19A20A22A23A24A19A21A22A23A24A37A31A26A27A28A133A31A26A27A28A32A330218041321831875541510242405912482661506011403691078056A34A36A3302744492048229707315141342209683766815055619429211839527A38A39A40A41A44A45A46A47A48A113A44A78A49A79A503P97A136A51A66A52A53A55A56A58A59A60A61A62A63A64A65A67A68A69A70A71A67A68A104A72A73A74A75A76A77A80A81A82A83A84A85A86A87A56A88A89A72A90A91A80A81A63A92A95A96A97TA98A99A843A231A10031A101A102A103A105A106A108A109A110A111A112A115A117A118A119A120A121A122A123A124A102A125A126A101A102A103A105A128A129A1283A131A134A135A248A137A139A140A141A142A143A144A145A146A147A148A149A150A140A151A152A207A153A154A155A207A156A157A154A158A159A160A161A162A158A163A164A165A166A167A168A170A171PA172001A174A1756A176A177A178A176A178A177A176A180A181A182A178A183T/HPLASMA/CSFCONCENTRATION/GML1PLASMASAMPLEOFBORNEOLGROUPCSFSAMPLEOFBORNEOLGROUPPLASMASAMPLEOFCONTROLGROUPCSFSAMPLEOFCONTROLGROUPA1843A185A186A187A188A189A190A191A192A193A194A195A196A197/A198A200A201A202A191A192A193A194A203A204A205A206A208A209A210A211A212FIG3MEANPLASMA/CSFCONCENTRATIONTIMECURVESOFTMAFTERINTRAGASTRICADMINISTRATIONINRABBITS32A213A214A215A216A217A218A219321A218A219A220A221A222A223A224A225A213A226A227A228A229A230A232A233A234A235A236A237A235A238A213A239A240A241A242A243A244A245A246A247A249A250A251A252A2533P97A254A255A115A0A1A2A3A4A5A6A7A8A9A10A11A134A111A251A0A1A242A68R2A12A239A13A14A251A18A25AICA12AKAIKESINFORMATIONCRITERIONA18A10A144A8A9A25A145A15A54A10A144A16A17A158R2A148A19A138AICA148A235A242A8A9A107A20A148A123A54A231A93A21A22A242A23A28A24A26A20A27A29A8A9A242A30A31A28A24A32A33A34A29A8A9A54A124A243A35A7A36A37A111A251A108A202A104A38A158A392A46A40A41A42A43A44A45A47A48A49A50A51A52A53A55A56A57A58A59A60A61A62A63TABLE2THEEFFECTSOFBORNEOLONPHARMACOKINETICPARAMETERSOFTMZINPLASMAOFRABBITSA59A60A149A64A46A40A65A66A67A69AGML133645932KEH10972306509KAH11038708221T1/2KAH0667308431T1/2KEH071291065TPEAKH099491364CMAXGML110408087AUCGML1H22121899CL/FSMGKG1/H/GML10426806319V/FCMGKG1/GML104390097097A703A71A72A66A73A74A75A76A77A78A79A80A81A82A83A84A85A86A87A88A89A90A91A92A94TABLE3THEEFFECTSOFBORNEOLONPHARMACOKINETICPARAMETERSOFTMZINCSFOFRABBITSA89A90A95A96A97A98A99A100A101A99AGML111911386ALPHAH115582703BGML128105952BETAH10699705218KAH110111850V/FCMGKG1/GML153995641T1/2A102H0444902565T1/2A103H099071329T1/2KAH0685403748K21H140433859K10H10269603654K12H120557448AUCGML1H10245821CLSMGKG1/H/GML114562062TPEAKH16651635CMAXGML132271740322A105A106A109A1103221A183A112A113A114A116A117A118A119A120A121A122A125A126A127A122A128A1292721099HVS136HA130PA141005A131A132A133A135A136A137A119A139A122A140A142A143A146A147167HVS164HA150A203A151A237A152A1533222A143A154A155A156A157A159A160A161A162A163A164A165A166A163A167A16828431039GML1VS809GML1A169PA170001A171A172A173A174A157A159A160A161A162A163A164A165A166A163A167A1688563323GML1VS174GML1A169PA170001A171A1753223AUCA176A177A210A178A179A180A181A18212MG/KGA184A161A162A163A185A165A166A163A159A164A184A156A157AUCA167A168ML1HVS1898GML1HPA170001A172A173A174A157AUCA167A168ML1HVS582GML1HPA170001A172A187A188A189A190A191A192A193A194A195AUCA196/AUCA197A198A199A200A201A204A205A206A201A207A20815634629VS3066PA209001A198A211A212A213A214A215A216A217A218A2194A241A22041A221A222A223A224A225A226HPLCA227A228A229A230A232A233A234A224A236A238A240A242A243A244A245A246A247A224A248A227A2495A2506A251A252A253A254A255A167A79A49A0A1A2A3ETHAZOLASTONEA64A0A1A18A2495A251A252A158A223ETHAZOLASTONEA103A4A159A182A252A253A0A182A85A5A173A252A217A253A0A6A7A8A1308A64A254A16A2A252A160A9A180A10A11A12A13A14A54A58A7A85A68A15A16A64A0A1A252A17A5A180A19A20A6A21A93A252A145A22A180A10A11A114A14A5442A23A51A24A25A153A26TMA27A161A28A119A29A30A31A32A119A163A33A34A35A92A36A115A23A51A24A153A26A152A37A38A31A166A39A40A41A81A42A43A168A44A455,6A46A47A170A48A133A172A50A52A174A53A55A56A202A57,TMA40A87A59A9605A75A76A60A6120A6280A53V/VA63A65A66A67A165A69A53A136A70A205A7124HA177A72A243A73A74A69A77A78A8043A82A83A84A86A88A89A90A91A94A95A97A98A99A100A101A102A82A83A88A89A90A91A104A105A106A107A215A108A175A109A138A213A110A107A111A112A113A116A117A118A120136HA121A122A123A147A124A125A126A127A128A123A185A176A143A129A111A131A132A134A123A135A131A137A112/A111A139A140A124A141A127A142A144A14630A123A248A148A149A150A151A154A155A156A157A113A162A16444A169A171A178A179A181A183A184A186A187A188A189A169A171A190A191A192A193A194A188A195A196A197A198A199A178A200A201A2031A204A206A207A208A209A210A211A212A2037A204A214A216A218A219A220A206A221A222A224A225A226A227A228A229A230A231A232A233T1/2KAA234TPEAKA235A236A206CMAXA237A208A206AUCA238A239A206A240A241A224A225A242A244A245A246A247A249A250A251A229A230A
温馨提示
- 1. 本站所有资源如无特殊说明，都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
- 2. 本站的文档不包含任何第三方提供的附件图纸等，如果需要附件，请联系上传者。文件的所有权益归上传用户所有。
- 3. 本站RAR压缩包中若带图纸，网页内容里面会有图纸预览，若没有图纸预览就没有图纸。
- 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
- 5. 人人文库网仅提供信息存储空间，仅对用户上传内容的表现方式做保护处理，对用户上传分享的文档内容本身不做任何修改或编辑，并不能对任何下载内容负责。
- 6. 下载文件中如有侵权或不适当内容，请与我们联系，我们立即纠正。
- 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
评论
0/150
提交评论