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黄酮及二氢黄酮母体对醛糖还原酶抑制活性测试A1A0A2A4A3A6A5A7A9A10A8A11A12A13A14A15A16A17A14A18A10A8100081A20A19A21A21A22A22A23A24A25A26A27A28A29A30A31A32A33A34A35A36A37A38A39A35A36A40A41A25A42A43A44A45A46A34A47A48A49A50A51A52A53A54A55A56A57A58A59A60A61A34A30A31A62A32A33A63A64A65A66A67A68A34A35A36A37A38A39A35A36A40A41A62A69A70A71A72A73A28A32A74A51A52A25A42A43A44A45A46A34A47A48A49A50A53A54A55A75A76A75A76A72A73A28A32A74A25A42A43A44A45A46A77A78A79A80A81A34A47A48A82A27A55A75A83A72A73A28A32A74A65A84A82A85A35A36A86A42A43A44A45A46A47A48A87A88A89A90A91A92A41A55A93A94A95A96A97A98A99A100A101A97A98A99A102A103A104A105A106A99A107A108A109A110INHIBITORYACTIVITYOFFLAVONONEANDFLAVONETOWARDALDOSEREDUCTASEWUTUOQI,SHENYI,ZHUCHANGJINDEPARTMENTOFAPPLIEDCHEMISTRY,BEIJINGINSTITUTEOFTECHNOLOGY,BEIJING100081,CHINAABSTRACTA111OBJECTIVESYNTHESIZEFLAVONEANDFLAVONONE,ANDTESTTHEIRINHIBITIONACTIVITYTOWARDSALDOSEREDUCTASEMETHODSBYUSINGANAPPROPRIATEAPPROACH,THENONSUBSTITUTEDFLAVONONEANDFLAVONEARESYNTHESIZEDTHENTHETWOCOMPOUNDSARETESTEDFORTHEIRINHIBITORYACTIVITYTOWARDALDOSEREDUCTASERESULTSTHETWOCOMPOUNDSHAVEINHIBITORYACTIVITYTOWARDSALDOSEREDUCTASECONCLUSIONTHETWOCOMPOUNDSCANBEUSEDASLEADCOMPOUNDSFORALDOSEREDUCTASEINHIBITORSKEYWORDSFLAVONEFLAVONONEALDOSEREDUCTASEINHIBITORYACTIVITYA112A113A114A115A116A117A118A119A120A121A122A123A124A125A126A127A128A125A114A117A129A130A131A132A133A134A129A135A119A136A114A129A137A114A138A139A140A141A142A143A144A145A146A147A148A149A150A151A152A153A154A155A143A156A157A158A159A160A161A162A163A164A165A166A167A168A169A167A168A166A170A171A172A173A170A169A174A143A175A176A154A155A148A177A151A148A160A161A162A163A164A151A143A178A179A180A181A182A183A184A180A165A185A168A186A167A187A188A189A188A186A190A191A171A170A187A188A192A193A194A185A189A174A143A195A196A197A198A199A200A201A202A156A203A204A205A206A207A208A209A176A210A211A212A213A160A214A175A211A215A216A148A217A218A219A220A221A222A203A223A205A148A224A199A225A221A222A203A226A205A148A224A227A228A229A221A222A203A230A205A231A206A232A233A143A234A235A236A227A228A237A185A238A185A144A145A239A240A143A156A241A242A144A145A146A147A148A243A244A245A246A211A151A247A248A249A250A143A207A208A251A252A253A207A208A176A210A211A254A255A181A182A183A184A180A213A29A0A143A1A2A221A222A203A3A8A9A205A206A243A244A245A246A211A151A164A4A247A248A249A250A254A185A189A212A213A1A2A215A216A143A207A208A209A176A210A211A148A61A5A176A210A211A143A6A177A7A10A197A11A12A13A14A148A153A207A208A251A252A253A207A208A67A150A182A152A153A160A15A16A154A17A203A3A8A18A205A80A59A19A20A247A248A249A250A7A69A11A12A143A176A210A211A148A49A21A22A23A24A25A148A191A19A254A184A192A26A27A28A30A206A156A68A4A31A32A33A143A244A245A184A192A159A34A201A211A148A163A49A48A35A36A16A249A250A37A38A211A148A245A39A222A227A166A149A40A247A248A166A2A148A211A41A247A248A249A250A42A43A33A44A143A38A211A203A45A205A206A216A46A254A210A47A50A143A207A208A51A252A253A207A208A67A150A176A210A211A52A53A54A175A211A215A216A55A56A148A220A57A54A61A58A214A176A210A211A254A185A189A143A1A2A215A216A148A222A60A62A63A64A50A11A12A193A76A143A212A213A185A189A1A2A215A216A143A176A210A211A206A227A227A227A227A227A227A227A227A227A227A227A227A227A227A227A227A227A227A227A227A65A66A70A71A72A73A74A75A77A78A77A79A81A82A83A84A85A85A86A87A65A66A72A88A89A90A77A78A77A91A92A77A93A81A84A94A95A96A97A98A72A99A100A101A100A102A103A104A105A106A104A107A108A104A109A110A111A112A113A98A114A115A116A117A118A119A113A120A121A97A122A123A121A116A1241实验部分11材料与试剂A228A213A56A125A126A159A127A128A247A129A130A148A233A131A228A222A30A235A159A47A141SDA30A235A148A236A126A132A133250GA206A56A125A153A239A222A134A126A135A213A136A49A137A138A139A20612酶抑制活性测试A243A140A141A140A243A180A143A36A16A228A213A36A16A142A221A153A143A255A248A249A250A144A145A52A53A206A243A162A23A138A146A143A30A235A165A147A148A150A151A152A153A154A155A156A151A157A237A238A158A159A160A161A163A244A165A244A167A168A169A170A171A172A173A174A175A176A178A179A180A181A183A150A148A184A185A186A187A188A188A151A189A190A193A194A179A195A181A196A197A198A199A200A202A179A190A193A203A190A193A204A205A206A207A199A208A209A170A210A199A208A212A213A240A214A215A179A173A217A218A204A179A219A221A223A224A225A158A226A202A229A204A179A230A231A232A234A241A242A203A245A246A174A226A232A204A230A247A251A252A253A247A179A205A206A207A254A255A170A45A66A203A243A244A0A244A158A232A39A1A234A2A241A242A241A242A205A0A160A249A250A3A4A5A6A203A205A241A242A46A7A8A170A106A9A195A181A49A223A153A186A114A179A50A10A11A12A13A229A204A55A14A114A57A15A244A158A16A157A245A246A173A226A232A204A218A198A199A200A202A203A205A60A17A46A7A8A170A106A9A195A181A49A223A153A186A114A179A50A10A11A12A13A229A204A55A14A114A57A15A244A158A16A179A245A246A173A226A232A204A218A198A199A200A202A203A18A19A20A46A7A8A21A231A0A160A63A209A250A3A170A179A45A207A243A160A154A155A22A203A65A241A242A46A7A8A170A195A181A24A64A67A23A25A26A71A35A179A72A201A73A27A203A74A67A106A75A75A28A29A205A0A245A160A22A154A78A241A159A154A155A22A203A162A245A30A79A31A179A81A31A32A75A28A4A252A226A83A33A34A30A232A234A2032结果与讨论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结论A117A182A118A119A120A216A121A122A123A125A126A127A128A129A130A131A132A133A134A135A136A137A138A140A135A136A142A143A144A145A146A147A148A149A150A151A152A153A154A155A156A157ARA134A158A159A160A161A146A168A163A134A165A166A167A170A171A172A174A176A177A178A152A153A154A155A156A179A180A181A143A171A183A184A185A150A134A186A187A188A189A144A145A190A191A171A192A193A168A163A194A192A195A196A134A157ARA192A158A159A160A161A179A177A134A135A136A197A154A155A156A146A198A197A154A155A156A192A193A179A180A199A200A134A202A203A204A205A206A147A207A208A210A211A212A156A146REFERENCES1JMPETRASHALLINTHEFAMILYALDOSEREDUCTASEANDCLOSELYRELATEDALDOKETOREDUCTASESCELLMOLLIFESCI6120047377492PHILLIPSWR,BAJNJ,GUNATILAKAALCGERANYLCOMPOUNDSFROMMIMULUSCLEVELANDIIJJNATPROD,1996,594953HUANGL,FULLASF,BROWNDMANEWPRENYLATEDFLAVONOLFROMTHEROOTOFPETALOSTENONPURPUREU
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