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高效液相色谱法测定兔血浆中注射用纳米羟基喜树碱的浓度A1A2A0A4A5A3A7A6A8A9A10A11A12A13A14A15A16A17A18A19A20A21A22A23A24A25A26A27A28A29A30A31A32A33A34A35A36A37A7A11A12A38A39A40A41A42A43A44A45A46A47A35A48A49A50A30A51A52A5310A54A55A56250A55A55A5746A55A55A58A59A60A56A61A62A63A6410A55A55A65A66A67A68A69A40A70A71A72A73A74A53A75A7640A60A77A78A79A5350A8050A60A56A61A8110A55A68A67A55A82A83A56A50A8430A85A56A86A31A87A88384A83A55A89A9050A55A91A67A92A91A93A25A94A95A96A10A97A98A99A100A101A14A17A18A19A20A21A22A23A102A43A103A104A105A106A107A108A109A11A31A32A110A111A112A113A89A114A115A7A19A20A21A22A23A116A117A106A107A6487A55A82A83A56A32A25A118A119A120A121A64208000A83A91A67A55A68A89A11A12A13A19A20A21A22A23A26A122A123A124A64969210351A56A125A126A127A128A113A129787A130A56A125A107A127A128A113A1291155A89A17A18A19A20A21A22A23A14A15A42A131A132A133A134A135A136A89A114A137A7A138A34A139A140A141A16A43A32A25A142A143A43A144A145A146A17A18A19A20A21A22A23A62A147A148A149A150A26A151A152A35A1A153A154A155A4A19A20A21A22A23A156A17A18A156A157A158A74A63A48A49A156A11A110A112A113DETERMINATIONTHECONCENTRATIONOFINJECTEDNANOHYDROXYCAMPTOTHECININPLASMAOFRABBITSBYHPLCABSTRACTOBJECTIVETOESTABLISHAHPLCMETHODFORTHEDETERMINATIONOFINJECTEDNANOHYDROXYCAMPTOTHECININPLASMAOFRABBITSMETHODSAFTERACIDTREATMENT,PLASMASAMPLESWEREINJECTEDANDMEASUREDBYABSTRACTIONTHECHROMATOGRAPHICCOLUMNWASC1810MA159250MMA16046MMIDMETHANNOL10MMOL/LPHOSPHATEBUFFERPH405050WASSERVEDASMOBILEPHASEAT10ML/MINDETECTIONWAVELENGTHWAS384NMDETERMINATIONTHECONCENTRATIONOFINJECTEDNANOHYDROXYCAMPTOTHECININPLASMAOFRABBITSAFTERIVADMINISTRATIONWITHTHEDOSAGEOF50MG/KGRESULTSTHERETENTIONTIMEOFHYDROXYCAMPTOTHECINWAS87MINAGOODLINEARITYWASSHOWNINTHECONCENTRATIONRANGEOF208000NG/MLTHERECOVERYWASBETWEEN9692AND10351THEINTRADAYRSDWASLESSTHAN787ANDTHEINTERDAYRSDWASLESSTHAN1155THECONCENTRATIONTIMECURVESOFINJECTEDNANOHYDROXYCAMPTOTHECINMAINLINECONFORMEDTOTHREECOMPARTMENTMODELCONCLUSIONTHISMETHODWASSIMPLE,PRACTICALANDACCURATEITCOULDBEAPPLIEDINPHARMACOKINETICSTUDYOFNANOHYDROXYCAMPTOTHECINKEYWORDSHYDROXYCAMPTOTHECINNANOHPLCDRUGCONCENTRATIONINPLASMAA161A162A163A164CAMPTOTHECIN,CPTA165A166A167A168A169A170A171A172A173A174A175A176A161A162A171A162A177A178A179A180A181A182A183A184A185A186A187A188A189A190A191A192A193A194A195A196A187A197A198A199A200A201A202A203A204A205A206A207A208A209A210A211A212A213A196A21410A215A216A217A218A179A199A21910HYDROXYCAMPTOTHECIN,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