抗氧化剂：让你延年益寿.ppt

1、抗氧化劑：讓你延年益壽Antioxidants: add life to your years,NuSkin presentation Taiwan November 3, 2007,雷派克 博士Prof. Lester Packer,百歲人瑞Centenarian,0,20,40,60,80,100,0,20,40,60,80,100,120,長壽人口增加後之存活率% Survival if % reduction in mortality at all ages occurs again,1985存活率1985 Survival,1900存活率1900 Survival,存活率 % OF

2、POPULATION SURVIVING,年齡分布 Chronological Age,健康長壽的趨勢Toward Healthy Aging,T.B.L. Kirkwood in Longevity: To the limits and Beyond. Ed. By J.M. Robine et.al. Published by Springer: Heidelberg, 1997.,0,20,40,60,80,100,Colon,Cancer,Stroke,Coronary,Disease,Diabetes Type 2,改變生活型態以預防疾病的發生 Diseases Avoidable

3、by a Change in Lifestyle,Walter Willett Science 296, 695-698: 2002,-,減少百分比 Percent avoidable,結腸癌,中風,冠狀動脈疾病,第二型糖尿病,US,China,亞洲國家Asian Countries,西方國家Western Countries,Int.J. Cancer (2000) 85:60-7,Courtesy Emily Ho,氧化壓力 Oxidative Stress,自由基造成氧化壓力Free radicals cause oxidative stress 導致組織壞死、老化及疾病的發生Leads

4、 to tissue damage, aging and disease,維生素C及E Vitamins C and E 多酚類(類黃酮) Polyphenols (Flavonoids) 硫氫基Thiols：麩胱甘肽 Glutathione,硫辛酸Lipoic Acid 輔酵素Q10 Co-enzyme Q,抗氧化劑 Antioxidants,類胡蘿蔔素 Carotenoids,氧化還原循環 Redox cycling,清除自由基 Radical scavenging,皮膚構造,角質層,表皮層,真皮層,紅斑 一種典型的曬傷後發炎反應,MED是紅斑的衡量單位。它是指少量的UVB照射24小時候後

5、，在皮膚產生些微的紅斑現象的評估。,人體角質層中的維生素E濃度,-生育醇,-生育醇,濃度 (pmol),濃度 (pmol),抗氧化網絡運作模式The Antioxidant Network in Membranes,維生素C循環Vit. C Cycle,脂質自由基 Lipid Free Radicals LOO LO,代謝 Metabolism,脂溶性環境 Fat Soluble,水溶性環境Water Soluble,水溶性環境Water Soluble,氧化代謝Oxygen Metabolism,蔬果中的類胡蘿蔔素 Carotenoids in fruits 27:833,人類視網膜,視網膜

6、,視神經,C. Smidt and D.S. Burke, Nutritional Significance and Measurement of Carotenoids, Current Topics in Nutraceutical Research 2004, 2, 79-91,0,20000,40000,60000,0,0.5,1,1.5,2,2.5,3,3.5,4,血清中類胡蘿蔔素總量 Total Serum Carotenoids (g/ml),Skin Raman Intensity (n = 372),r = 0.84 (p0.0001),p0.01,p0.01,p0.01,S

7、td. Error 44,Std. Error 38,Std. Error 61,Std. Error 106,24793,26639,29704,31507,10000,15000,20000,25000,30000,35000,1 or less,2 to 3,4 to 5,6 or more,Courtesy Stephen Poole, Pharmanex,Skin Raman Intensity (2005 US data of 209,628 Non-Supplement Users),每日食用水果及蔬菜份數Daily servings of fruits and vegetabl

8、es,良好的生活型態增進皮膚抗氧化類胡蘿蔔素 與掃描儀之研究 Lifestyle can improve carotenoid antioxidants in skin- Scanner studies,209,628位受試者 從未使用過營養補充品 結論：每日吃6份以上蔬果者，皮膚類胡蘿蔔素指數明顯增加,身體防禦指數,身體防禦指數,4毫克葉黃素4 mg Lutein, 杯烹煮過的菠菜 cup of cooked spinach,1又1/3根中型胡蘿蔔 或 杯南瓜 1 & 1/3 medium carrots or cup pumpkin,4毫克 b-胡蘿蔔素 4 mg b-Carotene,4

9、毫克蕃茄紅素 4 mg Lycopene,1顆中型番茄 或 茶匙番茄醬 1 medium tomato or Tsp tomato paste,營養補充品中的類胡蘿蔔素含量與天然食物的相對份量Carotenoids in human supplements equivalent to amounts in food (courtesy KJ Yuem),食用營養補充品後，血漿中總類胡蘿蔔素濃度增加Plasma Total Carotenoid Concentration Is increased after Supplementation,時間,日 Time, Day,D1,D15,D29,D

10、43,D57,Plasma Total Carotenoid (mg/dL),0,20,40,60,80,100,120,140,160,180,Placebo 對照組,Mixed Car 綜合類胡蘿蔔素,Lutein 葉黃素,b-Carotene b-胡蘿蔔素,Lycopene 蕃茄紅素,Significantly different from baseline 顯著差異 * p0.05,Courtesy KJ Yuem, et al.,血漿中總類胡蘿蔔素濃度(mg/dL),食用含類胡蘿蔔素的營養補充品在慧星分析法証實，可以保護人類淋巴球中的DNA免受破壞 Carotenoid Supple

11、mentation protects against DNA Damage in human lymphocytes The comet assay,第57天 Day 57,Courtesy KJ Yuem, et al.,維生素A在健康百歲人瑞體內含量顯著比年輕人高 Vitamin A levels are increased in healthy centenarians compared to younger subjects,Vitamin A (M),100歲 Centenarians, 60 歲,60-79歲,80-99 歲,153位義大利百歲人瑞 153 Italian centenarians, * p 0.0001,*,*,*,0,1,2,3,4,5,6,Christina Polidori, Eur J Clin Nutr 2007,(M),維生素A,酵素 & 蛋白質的誘導物 保護抗氧化劑 Inducers of enzymes & proteins needed for antioxid