饮酒、吸烟及幽门螺杆菌对胃部疾病患者血清、涎液和胃液中人表皮生长因子的影响

1、饮酒、吸烟及幽门螺杆菌对胃部疾病患者血清、涎液和胃液中人表皮生长因子的影响         08-09-17 08:44:00     作者：朱瑞龙     编辑：studa20【摘要】  目的 探讨饮酒、吸烟及幽门螺杆菌（Hp）感染对胃部疾病患者体液表皮生长因子（hEGF）的影响。方法 对来我院作胃镜检查的患者随机采样，采用快速尿素酶试验与组织学检测确诊幽门螺杆菌感染，通过问卷方式确定患者饮酒、吸烟的情况，hEGF测定用放射

2、免疫分析法（RIA）。结果 196例受检者中血清、涎液和胃液中hEGF水平，饮酒组与不饮酒组比较，P<0.01,吸烟组与不吸烟组比较，P<0.05,烟酒嗜好组与无烟酒嗜好组比较，P<0.025，上述各组血清中hEGF水平均差异有显著性,而各组涎液和胃液中hEGF水平的比较，差异无统计学意义（P>0.05）。Hp（+）组与Hp（-）组比较，血清中差异无统计学意义（P>0.05），而涎液和胃液中hEGF水平Hp（+）组均显著低于Hp（-）组，P<0.005。结论 饮酒、吸烟者血清中hEGF水平显著增高，与胃癌的发病可能有关;幽门螺杆菌感染者涎液和胃液中hEGF水

3、平显著降低，与消化性溃疡的发病密切相关。 【关键词】  饮酒 吸烟 人表皮生长因子 幽门螺杆菌    Investigation on levels of hEGF in serum,saliva and gastric juice of patients with gastric diseases by drinking,smoking and Hp    ZHU Rui-long,SHEN Wei-zhong,ZHU Qiu-ying,et al.Luodian Hospital of Baoshan District,

4、Shanghai 201908,China    Abstract  Objective  To investigate the levels of hEGF in serum,saliva and gastric juice of patients with gastric diseases by drinking,smoking and Hp.Methods  Patients were diagnosed by Hp infection through rapid urease test and histology detect

5、ion.Drinking and smoking conditions were investigated by questionnaire.hEGF was detected by RIA.Results  Among 196 cases,the levels of hEGF in serum of drinking and non-drinking groups,smoking and non-smoking groups,drinking with smoking and non-drinking with non-smoking groups were different,a

6、nd the differences were significant respectively.But the levels of hEGF in saliva and gastric juice were not different.The levels of hEGF in serum of Hp（+） and Hp（-） groups were not different,but in saliva and gastric juice were different,and the Hp（+） group was lower than Hp（-） group.Conclusion

7、0; The levels of hEGF are high in serum of drinking and smoking groups,so it may be related to gastric cancer.The levels of hEGF are low in saliva and gastric juice of Hp（+） group,so it may be related to peptic ulcer.    Key words  alcohol drinking；smoking;human  epidermal g

8、rowth factor;Helicobacter pylori    幽门螺杆菌（Hp）是慢性胃炎、消化性溃疡、胃癌的主要致病因子之一，饮酒、吸烟与人类的健康密切相关，人表皮生长因子（hEGF）是有广泛生物活性作用的细胞因子，与上述胃疾病有关，笔者对来本院作内镜检查者测定体液中hEGF水平，以探讨饮酒、吸烟及Hp感染对胃部疾病患者体液中hEGF的变化的影响。    1  对象和方法    1.1  对象  196例受检者中慢性胃炎65例（男43例，女22例，年龄1875岁，

9、平均44.2岁），胃溃疡（GU）36例（男30例，女6例，平均57.8岁），十二指肠溃疡（DU）48例（男41例，女7例，平均41.6岁），胃癌27例（男24例，女3例，年龄3581岁，平均64.9岁），健康人20例（男10例，女10例，年龄2253岁，平均40.0岁），所有受检者均经内镜和病理证实诊断。本实验分组：饮酒组24例，不饮酒组172例；吸烟组41例，不吸烟组155例；烟酒嗜好组23例与无烟酒嗜好组154例，以及Hp（+）组91例和Hp（-）组105例。    1.2  方法    2  结果 

10、   2.1  饮酒组与不饮酒组患者血清、涎液和胃液中hEGF水平比较  见表1。饮酒组与不饮酒组比较，血清中hEGF水平饮酒组显著高于不饮酒组，差异有统计学意义（P<0.01），而涎液和胃液中hEGF水平在饮酒组与不饮酒组相比，差异无统计学意义（P>0.05）。表1  饮酒与不饮酒的受检者血清、涎液和胃液中hEGF水平的比较 注：与不饮酒组比较，P<0.01    2.2  吸烟组和不吸烟组患者血清、涎液和胃液中hEGF水平比较  见表2。吸烟组与不吸烟组比较，血清中hEGF水平在吸烟组显著高于不吸烟组，差异有统计学意义（P<0.05），而涎液和胃液中hEGF水平在吸烟组与不吸烟组相比较，差异无统计学意义（P>0.05）。表2  吸烟与不吸烟的受检者血清、涎液和胃液中hEGF水平的比较注：与不吸烟组比较，P<0.05    2.3  烟酒嗜好组与无烟酒嗜好组患者血清、涎液和胃液中hEGF水平比较  见表3。烟酒嗜好组与