肿瘤指标浅谈临床科研ppt课件

1、 从肿瘤标志物浅谈临床科研从肿瘤标志物浅谈临床科研九区：方申存九区：方申存1;.住院号住院号标本标本CEACEANSENSECY211CY211SCCSCCCA125CA125CA199CA199121098胸水24.52202.541.7212240.1血2.37.082.340.9584.890.1122055胸水0.4916.4384.250.81290.32.44血0.89.382.510.4447.243.99122166胸水6.597.393.280.9146.2111.26血4.148.6856.141.4934.526.55122069胸水2.214.6676.912.3780

2、45.76血3.032.542.10.36142.615.27124406胸水0.898.0817.461.685248.23血1.6811.262.20.5171.7410.61124406胸水0.898.0817.461.68314.26.52血1.6811.262.20.5171.7410.61 127435胸水0.647.7611.850.74165.93.53血0.778.181.030.5762.266.09121128胸水0.383.0913.312.1379.32.87血0.5210.491.670.4489.665.89132990胸水0.618.9120.692.61189

3、21.21血0.6313.521.230.53119.14.49132668胸水1.6623.7660.125.71508.20.6结核性胸膜炎患者胸水中肿瘤标志物结核性胸膜炎患者胸水中肿瘤标志物2;.矽肺血清中肿瘤标志物矽肺血清中肿瘤标志物 机制研究（动物或细胞实验） 提出问题（TM 是否增高及意义）TM在矽肺血清中是否增高（矽肺与正常人比较）TM在矽肺增高的意义（TM与矽肺严重性的相关性分析） 个案病例分析 大样本分析比较 反向论证 TM为何增高或来源分析？ 比较灌洗液与血清TM浓度肺活检免疫组化 荧光免疫双染3;.矽肺血清中肿瘤标志物矽肺血清中肿瘤标志物1.矽肺与正常人血清中矽肺与正常人

4、血清中TM比较比较4;.矽肺血清中肿瘤标志物矽肺血清中肿瘤标志物2.个案相关性研究（不同时期矽肺血清个案相关性研究（不同时期矽肺血清TM变化）变化）5;.矽肺血清中肿瘤标志物矽肺血清中肿瘤标志物3.大样本相关性分析大样本相关性分析6;.矽肺血清中肿瘤标志物矽肺血清中肿瘤标志物4.反向论证反向论证7;.矽肺血清中肿瘤标志物矽肺血清中肿瘤标志物5.血清中血清中TM的来源（比较灌洗液和血清中的来源（比较灌洗液和血清中TM差别）差别）8;.矽肺血清中肿瘤标志物矽肺血清中肿瘤标志物6.血清中血清中TM的来源（肺活检组织免疫组化）的来源（肺活检组织免疫组化）9;.矽肺血清中肿瘤标志物矽肺血清中肿瘤标志物7

5、.TM来源何种细胞（荧光免疫双染）来源何种细胞（荧光免疫双染）10;.住院号住院号标本标本CEACEANSENSECY211CY211SCCSCCCA125CA125CA199CA199121098胸水24.52202.541.7212240.1血2.37.082.340.9584.890.1122055胸水0.4916.4384.250.81290.32.44血0.89.382.510.4447.243.99122166胸水6.597.393.280.9146.2111.26血4.148.6856.141.4934.526.55122069胸水2.214.6676.912.378045.76

6、血3.032.542.10.36142.615.27124406胸水0.898.0817.461.685248.23血1.6811.262.20.5171.7410.61124406胸水0.898.0817.461.68314.26.52血1.6811.262.20.5171.7410.61 127435胸水0.647.7611.850.74165.93.53血0.778.181.030.5762.266.09121128胸水0.383.0913.312.1379.32.87血0.5210.491.670.4489.665.89132990胸水0.618.9120.692.6118921.21

7、血0.6313.521.230.53119.14.49132668胸水1.6623.7660.125.71508.20.6血2.8714.72.40.6377.721.61结核性胸膜炎患者胸水中肿瘤标志物结核性胸膜炎患者胸水中肿瘤标志物11;.结核性胸膜炎患者胸水中肿瘤标志物结核性胸膜炎患者胸水中肿瘤标志物姓名姓名住院号住院号标本标本CEACEANSENSECY211CY211SCCSCCCA125CA125CA199CA199袁小露126914治疗前胸水0.383.0913.312.1379.32.87两周后胸水0.272.885.81.52139.72.92三周后胸水0.4321.543.

8、431.4226.762.96王燕127435胸水0.647.7611.850.74165.93.53一周后胸水0.5117.459.690.43120.22.92刘翠英128540胸水1.132.2228.180.49861.70.6二周后胸水1.89.39.630.6774.2720.86抗结核治疗前后胸水中抗结核治疗前后胸水中TM变化变化12;.结核性胸膜炎患者胸水中肿瘤标志物结核性胸膜炎患者胸水中肿瘤标志物1.血清血清CA125与肺结核与肺结核The value of CA-125 in the evaluation of tuberculosis activity.Respir Me

9、d. 2001;95(8):666-9.13;.结核性胸膜炎患者胸水中肿瘤标志物结核性胸膜炎患者胸水中肿瘤标志物2.血清血清CA125与肺结核与肺结核Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment.Clin Invest Med. 2012;35(4):223-8.注：Group1:活动性肺结核；Group2：非活动性肺结核：Group3:正常人14;.结核性胸膜炎患者胸水中肿瘤标志物结核性胸膜炎患者胸水中肿瘤标志物3.血清血清CA125与肺结核与肺结核Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment.Clin Invest Med. 2