异氟醚、恩氟醚对罗库溴铵残余肌松作用的影响

1、异氟醚、恩氟醚对罗库溴铵残余肌松作用的影响何良英(广东省从化市中心医院麻醉科 邮编 510900)金来明赵汉民(广东省从化市中心医院普外科 510900)摘要目的观测异氟醚、恩氟醚对罗库溴铵的残余肌构作用的影响。方法选择58例ASA-级成年择期全麻手术病人，随机分为三组：丙泊酚组(组，21例)；异氟醚组(组，20例)；恩氟醚组(组，17例)。全麻诱导气管插管后罗库溴铵均以600mg·kg-l·h-1的速度静脉泵入。组丙泊酚泵入速度为4-lOmg·kg-1·h-l，组、组分别吸入呼气末浓度为1MAC的异氟醚或恩氟醚，使用Biometer加速度仪观测T1恢复

2、至25%、75%及TOF比值(T4T1)恢复至O.7的时间。结果三组间病人的性别、年龄、体重、身高、芬太尼总量、麻醉持续时间、血液动力学变化均无显著性差异(PO.05)。上述恢复时间，组、组与组比较均延长，有显著差异(P0.05)；、组比较差别无统计学意义(P0.05)。三组间恢复指数(Tl从25%-75%时间)比较无显著差异(PO.05)。结论异氟醚、恩氟醚均可延长罗库溴铵的残余肌松作用，但两者比较无明显差别。临床应用中应注意监测四个成串刺激(TOF)等，减少术后残余肌松作用所致的并发症。关键词 罗库溴铵；异氟醚；恩氟醚；肌松药A comparison of effects of isofi

3、urane and enflurane on the residual curarization following rocuronium admini stration.He L iangying3Jin Laiming, Zhao Hanmin(DepaHment of Anae sthesian, Conghua Center Hospital 9Guangdong, Conghua 5l0900,China)Abstract Obj ective To investigate the effects of 1MAC isoaurane or enfiurane on postopera

4、tive residual curarization caused by rocuronium(home-made vecuronium).Methods 5 8 adult patients of ASA grade - undergoing selective operation under general anesthesia were randomly divided into three groups. Propofol group(group I，n=21)，Isonurane gropu(group s n=20)and ennurane group(group ，n=l7).

5、Afier general anesthesia induction，all patients were continuously infused with rocuronium at a rate of 600m·kg-1·h-1group I was continuously infused with propofol at rate of 4-10mg. kg-1. h-1. Group and inhaled 1MAC isoaurane.Or enfiurane respectively. T1 25% and T1 75% recovery time were

6、moni-toted by acceleromyograph as well as the 0. 7recovely time of TOF-ratio(T4/T1).Results There were no significant differences among three groups with respect to sex, age, body weight and height, total usage amount of fentany1, anesthesia duration and their blood dynamics parameters (P.>O.05).

7、Between grorp or and group 13 there were significant differences in TI25% and TI75% recovery time(P<O.05).The recovery time of group and was later than that of group I. Conclusion Both isofluraneand enflurane can increase the residul curarization of rocuronim. Monitoring of TOF should be emphasized during anesthesia in o