内分泌总论（课堂PPT）

1、www.drsun.haoDF.com.Endocrine and Metabolic Diseaseswww.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.神经系统神经系统Nervous system内分泌系统内分泌系统 Endocrine system免疫系统免疫系统Immune systemwww.drsun.haoDF.com.www.drsun.haoDF.com.返回返回www.drsun.haoDF.com.返回返回www.drsun.haoDF.com.Endocrine Endocrine systemsyst

2、emEndocrine Endocrine glandsglandsEndocrine Endocrine tissues tissues and cellsand cellsBody fluid Body fluid regulatedregulated systemsystemStartling EHStartling EH: : 19021905,Lancet 1905;2:33934119021905,Lancet 1905;2:339341神经与内分泌独立控制胰腺分泌及胃肠功能；神经与内分泌独立控制胰腺分泌及胃肠功能；Hormone=hormon(Hormone=hormon(压力、

3、逼迫压力、逼迫) )、hormao(hormao(运动运动) )Penole:Penole:Endocrine=Endo(内部内部)+Krine(分泌分泌) 内分泌内分泌系统系统内分泌腺内分泌腺内分泌组内分泌组织织/ /细胞细胞体液调节系统体液调节系统www.drsun.haoDF.com.gonadsPituitary glandThyroid glandAdrenal glandsParathyroidovariesovariestestestesteswww.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.Target ce

4、ll Target cell Endocrine cellEndocrine cellTarget cell Target cell EndocrineParacrineAutocrineIntracrinewww.drsun.haoDF.com.几乎所有细胞均是内分泌细胞几乎所有细胞均是内分泌细胞! !www.drsun.haoDF.com.返回返回www.drsun.haoDF.com.www.drsun.haoDF.com.HormonesHormonesMetabolism:Metabolism:carbohydrate,carbohydrate, lipid, Protein, li

5、pid, Protein, energy, energy,Electrolyte, Electrolyte, etc.etc.代谢代谢 Reproduction, Growth and Development, etc.生命过程Physiology:Respiratory , Circulatory ,Digestive , Hematogenic,Etc.生理Maintenance of internal Environment内环境稳定NSMetab.www.drsun.haoDF.com.返回返回www.drsun.haoDF.com.Hormone, a group of chemic

6、al messengers manufactured by endocrine glands, regulate the function of all vital organs.www.drsun.haoDF.com.Endocrine cellTarget cellTarget cellIntracrinewww.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com. Synthesis-Release-Transport-Receptors-Secondary messengers-Physiological effectPMRC

7、PR激素合成、运输激素合成、运输受体结合、第二信使、生物活性受体结合、第二信使、生物活性www.drsun.haoDF.com.细胞膜受体细胞膜受体www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.细胞核受体细胞核受体www.drsun.haoDF.com.作用于特异性受体作用于特异性受体 以以ug, ng, fg, pgug, ng, fg, pg计量计量 协同作用协同作用(synergistic action)(synergistic action) 拮抗作用拮抗作用(antagonistic action)(antag

8、onistic action) 允许作用允许作用(permissible action )(permissible action )MS,S,MIN,H,DayMS,S,MIN,H,Day是生理调节物质是生理调节物质作用的特异性作用的特异性不产生新功能，使原不产生新功能，使原有的功能增强或减弱有的功能增强或减弱血液浓度很低，活性很大血液浓度很低，活性很大分泌呈节律性分泌呈节律性激素之间相互作用激素之间相互作用不同激素作用时限不同不同激素作用时限不同激素的分泌及灭活呈激素的分泌及灭活呈动态平衡动态平衡www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsu

9、n.haoDF.com.返回返回www.drsun.haoDF.com.www.drsun.haoDF.com.Target glandTarget glandCNSCNSHypothalamusHypothalamusPituitaryPituitaryTarget organ/cellTarget organ/cellPhysical actions Physical actions and metibolismand metibolismwww.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.

10、com.www.drsun.haoDF.com.www.drsun.haoDF.com.（1 1）负反馈调节）负反馈调节（Negative)TRH-TSH-T3+T4CRH-ACTH-COrtisolwww.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.insulininsulinwww.drsun.haoDF.com.血钙血钙/磷磷CTPTHwww.drsun.haoDF.com.Endocrine Endocrine systemsystemNervousNervous systemsystemImmune Immune s

11、ystemsystem 神经介质神经介质肽类激素肽类激素抗体抗体共共 同同 受受 体体 www.drsun.haoDF.com.返回返回www.drsun.haoDF.com.Endocrine disorders Hormone deficiencyHormone deficiencyHormone overproductionProduction of abnormal hormoneDisorders of hormone receptorsAbnormalAbnormal of hormone transporttransport or metabolismmetabolismMult

12、iple hormone abnormalitiesMultiple hormone abnormalitiesTumors that produce hormonesTumors that produce hormoneswww.drsun.haoDF.com.www.drsun.haoDF.com. Primary deficiency Hypofunction of Endocrine GlandsE.g.: Primary HypothyroidismT3,T4 Hypo-TSH Hyper- Secondary deficiency Hypofunction secondary to

13、 hypothalamus andhypothalamus and pituitary pituitaryE.g.: Seconary HypothyroidsiumT3,T4 Hypo-TSH Hypo-www.drsun.haoDF.com. Primary overproduction Hyperfunction of endocrine glands Secondary overproductionHyperfuntion secondary to hypothala-mus and hypothala-mus and pituitarypituitaryE.g.: Primary H

14、yperthyroidismT3,T4 Hyper-TSH Hypo-E.g.: Seconary HyperthyroidsiumT3,T4 Hyper-TSH Hyper-www.drsun.haoDF.com.功能正常继发性继发性www.drsun.haoDF.com.原发性减退：内分泌腺本身功能原发性减退：内分泌腺本身功能减退所致：如原发性甲减减退所致：如原发性甲减T3，T4TSH继发性减退：下丘脑或垂体功能继发性减退：下丘脑或垂体功能减退所致的靶腺功能减退：如继发减退所致的靶腺功能减退：如继发性甲减性甲减TSHTSHT3、T4www.drsun.haoDF.com.www.drsun

15、.haoDF.com.www.drsun.haoDF.com.原发亢进：由于腺体本身功能亢进所致的异常；如原发性甲亢T3，T4TSH继发亢进：由于下丘脑或垂体功能亢进所致的靶腺功能亢进。如继发性甲亢TSHT3、T4原发亢进：由于腺体本身功能亢进所致的异常；如原发性甲亢www.drsun.haoDF.com.www.drsun.haoDF.com.返回返回www.drsun.haoDF.com.返回返回www.drsun.haoDF.com.C C、The The diagnostic diagnostic routineroutine of Endocrine diseases(1) of Endocrine diseases(1)返回返回www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.www.drsun.haoDF.com.返回返回www.drsun.haoDF.com.www.drsun.haoDF.com.131