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15、186;¦ ¡¾Abstract¡¿ Objective Evaluated the reduced glutathione to prevent and treat liver function impairment after chemotherapy.Methods 27 gastric£¬large intestinal and breast cancer patients with postoperative hepatic dysfunction were divided into A1 and A2 group

16、s. 21 primary or metastatic liver cancer patients were divided into C1 and C2 groups. The liver function was normal before chemotherapy. A1 and C1 groups were given TAD 1.2g ivgtt qd from 1d before chemotherapy to 1wk after chemotherapy£»A2 and C2 groups were not given TAD. 14 gastric£

17、;¬large intestinal and breast cancer patients with liver function impairment after chemotherapy (B group) and 11 primary or metastatic liver cancer patients with hepatic dysfunction (D group) were given TAD 1.2g ivgtt qd from detected abnormal liver function to 1wk after chemotherapy. The patie

18、nt¡¯s liver function was tested.Results The incidence of liver function impairment of A1 group 1wk after chemotherapy was significantly lower than that of A2 group (P<0.05). The ALT level of A1 group 1d and 1wk after chemotherapy was significantly lower than that of A2 group (P&

19、lt;0.05)£¬the ALT level of C1 group 1wk after chemotherapy was significantly lower than that of C2 group (P<0.05).Conclusion The reduced glutathione can prevent and cure liver function impairment after chemotherapeutic drug effectively£¬and has no influence on chemotherape

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