ANCA相关性血管炎肾损害病理表现PPT学习教案

1、会计学1ANCA相关性血管炎肾损害病理表现相关性血管炎肾损害病理表现P-ANCA Perinuclear PatternAnti-myeloperoxidaseMPO-ANCAC-ANCA Cytoplasmic PatternAnti-Proteinase 3PR3-ANCAAnti-Neutrophil Cytoplasmic Autoantibodies (ANCA)第1页/共17页Large Vessel VasculitisGiant Cell ArteritisTakayasu ArteritisMedium Vessel VasculitisPolyarteritis Nodos

2、aKawasaki DiseaseSmall Vessel VasculitisANCA-Associated Vasculitis（AASV）Microscopic PolyangiitisGranulomatosis with Polyangiitis (Wegeners)Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)Immune Complex VasculitisAnti-GBM DiseaseIgA Vasculitis (Henoch-Schnlein)Cryoglobulinemic Vasculitis

3、Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis)Variable Vessel Vasculitis (Cogans, Behcets, etc.)Single Organ Vasculitis (cutaneous SVV, primary CNS vasculitis, etc.)Vasculitis Associated with Systemic Diseases (e.g. Rheumatoid, Lupus, Sarcoid, etc.)Vasculitis Associated with Probable

4、 Etiologies (e.g. HBV, HCV, drug, cancer, etc.) 2011 Chapel Hill Consensus Conference Vasculitis Nomenclature第2页/共17页ANCA相关小血管炎肾损害病理表现第3页/共17页第4页/共17页细胞性新月体细胞性新月体纤维细胞性新月体纤维细胞性新月体第5页/共17页小叶间动脉纤维素样坏死小叶间动脉纤维素样坏死肾间质大量炎症细胞浸润肾间质大量炎症细胞浸润第6页/共17页小叶间动脉纤维素样坏死，内膜水肿伴炎症细胞浸润肾间质大量炎症细胞浸润小叶间动脉纤维素样坏死，内膜水肿伴炎症细胞浸润肾间质大量炎症细胞浸润第7页/共17页慢性化表现：小叶间动脉管腔内水肿，炎症细胞浸润慢性化表现：小叶间动脉管腔内水肿，炎症细胞浸润 血管腔内膜和肌层均纤维化血管腔内膜和肌层均纤维化第8页/共17页第9页/共17页第10页/共17页第11页/共17页第12页/共17页IgG400第13页/共17页左：纤维素样坏死左：纤维素样坏死右：从一个纤维素样坏死病灶蔓延至相邻小新月体右：从一个纤维素样坏死病灶蔓延至相邻小新月体Fibrin400第14页/共17页毛细血管袢基底膜断裂毛细血管袢基底膜断裂第15页