《新生研讨课》The Report Of SARS

1、? ?新生研讨课新生研讨课?The Report Of ?The Report Of SARSSARS2022-5-4Part One:What is SARS2022-5-4In April 16, 2003,WHO announceda new-style coronavirus is the pathogen of SARSThe virus is likely to come from the animal, because of the increasing fitness of coronavirus to infect humans, and finally spreaded a

2、mong people。WHOWHO2022-5-4Single-stranded RNA virusGenome, containing 29736 nucleotidesEnvelopeSpinous processIt is sensitive to heat and acid.SARS-Coronary virus2022-5-4Morphological structure:Irregular shapeDiameter:about 60-220 nanometer2022-5-4The membrane surface of virus has three kinds of pro

3、tein.Spike Protein Envelope ProteinMembrane ProteinA few species have hemagglutinin protein.2022-5-4Coronavirus stranded ribonucleic acid is single stranded27-31kd(a unit of biology)RNA virus ribonucleic acid chain is the longest Important structural characteristics 2022-5-4Between DNA and RNA of co

4、ronavirus recombination rate is very high。The virus changesChanges in the RNAAmino acid sequence changed Amino acids protein changes.Its antigenic changesThe immunization is fail.2022-5-4Genetic central dogma2022-5-415 different virus strains Mammals and birdsSome can cause disease.The RNA genome of

5、 virusViral RNA polymerase Using this enzyme the transcription of sub-genomic RNA，the synthesize of mRNA and the reproduce of the viral genome. 2022-5-4There is no shear process after transcription, but directly through the RNA polymerase and transcription factors by discontinuous transcription and

6、transcription regulating sequences.After the replication of Structural protein and genomic RNA is completed , it will be assembled new coronavirus in the host cells endoplasmic reticulum . And then and through the Golgi secretion to the extracellular.2022-5-4Part：twoThe symptom of SARS After knowing

7、 what is SARS,now we need to have a more thorough understanding of the symptom of SARS.2022-5-4 1.Early : Generally for 1 7 days at the beginning of the disease. Acute onset , with fever as the first symptom, body temperature above 38 , headache, more than half of the patients have joint and muscle

8、pain, fatigue and other symptoms, some patients may have a dry cough, chest pain, diarrhea and other symptoms . more than 95% of patients had positive change in the course of 7 days.2022-5-4 2.progress: occurred in the course of 8 14 days, individual patients may be longer. During this period, fever

9、 and infection symptoms persist, lung disease , progressive, manifested as chest tightness, shortness of breath, dyspnea , especially in the activities after the obvious. X-ray examination of the lungs shadow is developing rapidly, and often multi lobe lesion. A few patients (10% 15%) ARDS and endan

10、ger life.2022-5-4 3. Convalescence: after a period of progress, the temperature drops gradually , clinical symptoms, pulmonary lesions began to absorb, the majority of patients after 2 weeks of recovery, can reach the discharge standard, pulmonary shadow absorption will require a longer time. Most o

11、f them can be discharged from the hospital after 2 3 months recovered gradually.2022-5-4 Complication Shock, arrhythmia or cardiac insufficiency, renal function, liver function damage, DIC, sepsis, hemorrhage of digestive tract.2022-5-4 The SARS virus is not likely to be wiped out in the short term

12、and disappear automatically. Re-emergence of SARS in humans is very likely. The animal is still possible source of the virus, people still generally susceptible to SARS virus.2022-5-4 The SARS threat to human and harm will be long-term, the possibility of another epidemic， even large-scale popular s

13、till exist, to some extent,sporadic, from animal virus cases are impossible to guard against, but itsspread and population density, population flow and preventive control strategy and measures closely related to.2022-5-4 From 2002-2003 years experiences of prevention and treatment, hospital infectio

14、n control work has been strengthened, diagnostic reagent has been used, is conducive to timely detection of patients. So, SARS is preventable and curable.2022-5-4 SARS phobia does more harm than SARS2022-5-4 Professor Zeng，the current epidemiology training program executive director of China,epidemi

15、ological field in Guangdong Province， noted that now in the society SARS phobia is more serious than SARS itself.Some people have recently been in injection of thymosin, placental globulin toenhance immunity, 2022-5-4 Professor Zeng think it is entirely unnecessary. At present,SARS patients are most

16、ly in people between 20 to 40 , this is mainly because young people contact the society widely, having more chances of infection. 2022-5-4 But there is no cure for the fight against SARS at present, the vaccine research is time, individual drugs can temporarily improve immunity, but the SARS and no

17、preventive and protective effects of specific, some people mistakenly think that the injection is the insurance, usually do not pay attention to hygiene, but increased the possibility of infection.2022-5-4 Part three : Prevention of SARSSequelae of SARS pulmonary fibrosisosteoporosisfemoral necrosis

18、the most effective means to prevent the spread of SARS . Avoid contact with bodily fluidsBlock out virusesGood habit in daily life. Avoid contact with bodily fluids Continue with precautions for at least 10 days after the persons signs and symptoms have disappeared. Keep children home from school if

19、 they develop a fever or respiratory symptoms within 10 days of being exposed to someone with SARS. Wash personal items in hot, soapy water including the eating utensils and dishes, bedding and clothing of someone with SARS.Block out viruses handwashing, use of universal precautions, disinfection of surfaces for fomites, and use of a surgical mask are recommended.But how can we do in the daily life? Disinfection measures Some common disinfectants can kill within 5 minutes of SARS viruses, including: acetone; 10% formaldehyde an