R-PQ-912-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(R)-PQ-912Cat. No.: HY-123821BCAS No.: 1276021-64-7分式: CHNO分量: 336.39作靶点: Amyloid-作通路: Neuronal Signaling储存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性数据体外实验 DMSO : 200 mg/mL

2、 (594.55 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.9727 mL 14.8637 mL 29.7274 mL5 mM 0.5945 mL 2.9727 mL 5.9455 mL10 mM 0.2973 mL 1.4864 mL 2.9727 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配

3、，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 5 mg/mL (14.86 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 5 mg/mL (14.86 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 5 mg

4、/mL (14.86 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 (R)-PQ-912氨酰胺酰环化酶 (QC) 抑制剂，对氨酰胺酰环化酶的 IC50 值为 30.2 M，Ki 值为 7.25 M，详细信息请参考专利献 WO2011029920A1 中的 Example 13 1。REFERENCES1. Ulrich Heiser, et al. Heterocylcic derivatives as inhibitors of glutaminyl cyclase.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: