Hydroxyurea-Hydroxycarbamide-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHydroxyureaCat. No.: HY-B0313CAS No.: 127-07-1Synonyms: Hydroxycarbamide分式: CHNO分量: 76.05作靶点: DNA/RNA Synthesis; Autophagy; Apoptosis作通路: Cell Cycle/DNA Damage; Autophagy; Apoptosis储存式: Powder -20C 3 years4C 2 yearsIn solvent -8

2、0C 6 months-20C 1 month溶解性数据体外实验 H2O : 55 mg/mL (723.21 mM)DMSO : 50 mg/mL (657.46 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 13.1492 mL 65.7462 mL 131.4924 mL5 mM 2.6298 mL 13.1492 mL 26.2985 mL10 mM 1.3149 mL 6.5746 mL 13.1492 mL请根据产品在不同溶剂中的溶解度，选择

3、合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Hydroxyurea 通过抑制核糖核苷酸还原酶抑制 DNA 合成的细胞凋亡诱导剂。体外研究Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases 1.Treatment of cells in primary culture with 30 M hydroxyurea for 96 hours significantly increases the

4、1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEfractional HbF content. The G: A-globin mRNA is induced 0.30- to 8-fold in vitro 2. Hydroxyurea has beenshown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cellsand macrophages 3.体内研究 Hydroxyurea the

5、rapy producs consistent reductions in WBC and ANC without improvement in anemia over17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count andno improvement in anemia compared to vehicle treated sickle cell mice 4.PROTOCOLAnimal Mice: To determine wheth

6、er hydroxyurea would improve anemia and/or prevent or diminish the developmentAdministration 4 of organ damage in the absence of HbF induction, hydroxyurea, at doses of 25 mg/kg, 50 mg/kg, and 100mg/kg, or vehicle is administered five days per week to SCD mice 4.MCE has not independently confirmed t

7、he accuracy of these methods. They are for reference only.户使本产品发表的科研献 J Mol Med (Berl). 2019 Jun 14. J Cell Mol Med. 2019 Jul 23.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Kovacic P, et al. Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl,

8、radicals, cell signaling and clinicalapplications. Med Hypotheses. 2011 Jan;76(1):24-31.2. Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin Epatients. Exp Hematol. 2005 Dec;33(12):1486-92.3. Lori F, et al. Rationale for

9、the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl2:S193-7.4. Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica.2010 Sep;95(9):1599-603.McePdfHeightCaution: Product has not been fully validated for medica