CP-809101-hydrochloride - 5-HT Receptor Agonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECP-809101 hydrochlorideCat. No.: HY-15543ACAS No.: 1215721-40-6分式: CHClNO分量: 341.24作靶点: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 20

2、 mg/mL (58.61 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.9305 mL 14.6524 mL 29.3049 mL5 mM 0.5861 mL 2.9305 mL 5.8610 mL10 mM 0.2930 mL 1.4652 mL 2.9305 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 CP-809101 hydrochloride5-HT2受体激动剂，对5-HT2C/5-HT2B

3、/5-HT2A受体的pEC50分别为9.96/7.19/6.81。REFERENCES1. Higgins GA, Silenieks LB, Lau W, et al. Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food andnicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90.1/2 Master of Small Molecules 您边的

4、抑制剂师www.MedChemE2. Strong PV, Christianson JP, Loughridge AB, et al. 5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-inducedinterference with negatively reinforced instrumental escape behavior. Neuroscience. 2011 Dec 1;197:132-44. doi:10.1016/j.neuroscience.2011.09.041. Epub 2

5、011 Sep 24.3. Fletcher PJ, Tampakeras M, Sinyard J et al. Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feedingbehaviour in 5-HT(2C) receptor knockout mice. Neuropharmacology. 2009 Sep;57(3):259-67. doi: 10.1016/j.neuropharm.2009.05.011.4. Siuciak JA, Chapin DS, McCarthy SA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychoticactivity. Neuropharmacology. 2007 Feb;52(2):279-90.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3