Tirabrutinib-ONO-4059-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETirabrutinibCat. No.: HY-15771CAS No.: 1351636-18-4Synonyms: ONO-4059; GS-4059分式: CHNO分量: 454.48作靶点: Btk作通路: Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 m

2、g/mL (220.03 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2003 mL 11.0016 mL 22.0032 mL5 mM 0.4401 mL 2.2003 mL 4.4006 mL10 mM 0.2200 mL 1.1002 mL 2.2003 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(

3、为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.50 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.50 mM); Clear solution1/2 Master of Small Mol

4、ecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.50 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Tirabrutinib (ONO-4059)选择性，可服的 BTK 抑制剂， IC50 为2.2 nM。IC50 & Target IC50: 2.2 nM (BTK) 1户使本产品发表的科研献 Stem Cell Rep. 2019 Apr.See more customer validations on HYPERLINK / w

5、ww.MedChemEREFERENCES1. Burger JA. Brutons tyrosine kinase (BTK) inhibitors in clinical trials. Curr Hematol Malig Rep, 2014 Mar, 9(1):44-9.2. Harriet S. Walter et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cellmalignancies. Blood, 2016 Jan 28, 127(4): 411-419.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02