Plumbagin-2-Methyljuglone-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPlumbaginCat. No.: HY-N1497CAS No.: 481-42-5Synonyms: 2-Methyljuglone分式: CHO分量: 188.18作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 150 mg/mL (797.11 mM)H2O : 40% PE

2、G300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (13.29 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (13.29 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Plumbagin (2-Methyljuglone)是从 Plumbago zeylanica L 中得到的萘醌类物质，具有抗肿瘤、抗增殖

3、活性1。体外研究 Plumbagin (0, 5, 10, and 15 M) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1and LNCaP, in a dose-dependent manner 1.Plumbagin (5, 20 M) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells 1.Apoptosis Analysis 1Cell Line: DU145, CWR22rv1, LNCaP and RW

4、PE-1 cellsConcentration: 0, 5, 10, and 15 MIncubation Time: 24 hoursResult: Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed noeffect on RWPE-1 cells at up to 20 M.体内研究 Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nu

5、demice 1.Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKC, suppresses JAK-2 andStat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice 1.Animal Model: Male athymic nude mice bearing DU145 cells 1Dosage: 2 mg/kgAdministration: I.P. after 3 days post

6、 cell implantation, five days a week.Result: Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice.REFERENCES1. Aziz MH, et al. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008 Nov 1;68(21):9024-32.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: