Cevimeline-hydrochloride-hemihydrate - mAChR Agonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECevimeline hydrochloride hemihydrateCat. No.: HY-76772CAS No.: 153504-70-2分式: CHClNOS分量: 435.09作靶点: mAChR作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O

2、: 50 mg/mL (114.92 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2984 mL 11.4919 mL 22.9837 mL5 mM 0.4597 mL 2.2984 mL 4.5967 mL10 mM 0.2298 mL 1.1492 mL 2.2984 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Cevimeline盐酸半合物是毒蕈碱型

3、受体激动剂。REFERENCES1. Iga Y, Arisawa H, Ogane N, Saito Y, Tomizuka T, Nakagawa-Yagi Y, Masunaga H, Yasuda H, Miyata N. (+/-)-cis-2-methylspiro1,3-oxathiolane-5,3-quinuclidine hydrochloride, hemihydrate (SNI-2011, cevimeline hydrochloride) induces saliva and tear secretions1/2 Master of Small Molecules

4、您边的抑制剂师www.MedChemE2. Omori Y, Asari T, Maruyama K, Kusama H, Kojima M, Shibata N. Effects of pilocarpine hydrochloride and cevimeline onsubmandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation. Arzneimittelforschung. 2003;53(5):342-50.3. Washio, Takuo; Kohsaka, Kazu

5、hiro; Arisawa, Hirohiko; et al.Pharmacokinetics and metabolism of radiolabeled SNI-2011, a novelmuscarinic receptor agonist, in healthy volunteers: Comprehensive understanding of absorption, metabolism and excretion using radi4. Washio, Takuo; Kohsaka, Kazuhiro; Arisawa, Hirohiko; et al.Pharmacokine

6、tics and metabolism of the novel muscarinic receptor agonistSNI-2011 in rats and dogs.Arzneimittel-Forschung (2003), 53(1), 26-33.5. Arisawa, Hirohiko; Fukui, Kenji; Imai, Eiichi; et al.General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, adrug for xerostomia in Sjogrens syndrome. Arzneimittel-Forschung (2002), 52(4), 225-232.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: