JI051 - Notch 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEJI051Cat. No.: HY-117113CAS No.: 2234281-75-3分式: CHNO分量: 364.44作靶点: Notch作通路: Neuronal Signaling; Stem Cell/Wnt储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (342.99 mM; Need ult

2、rasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7439 mL 13.7197 mL 27.4394 mL5 mM 0.5488 mL 2.7439 mL 5.4879 mL10 mM 0.2744 mL 1.3720 mL 2.7439 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适

3、当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.71 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.71 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 JI051种 Hes

4、1-PHB2 相互作稳定剂，能够与癌症相关蛋伴侣 prohibitin 2 (PHB2) 相互作，通过抑制Notch 下游效应 因 Hes1 来诱导细胞周 期停滞。具有抗肿瘤作 1。体外研究 JI051 causes G2/M cell-cycle arrest 1.JI051 (0.1-10 M, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 M1.Cell Proliferation Assay 1Cell Line: HEK293 cellsConcentr

5、ation: 0.1-10 MIncubation Time: 24 hoursResult: Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.REFERENCES1. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0