Triptonide-NSC-165677-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETriptonideCat. No.: HY-32736CAS No.: 38647-11-9Synonyms: NSC 165677; PG 492分式: CHO分量: 358.39作靶点: Wnt; -catenin作通路: Stem Cell/Wnt储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (139

2、.51 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7903 mL 13.9513 mL 27.9026 mL5 mM 0.5581 mL 2.7903 mL 5.5805 mL10 mM 0.2790 mL 1.3951 mL 2.7903 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；

3、澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.98 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 Triptonide(NSC 165677; PG 492)从雷公藤中提取，抑制由伴球蛋A或脂多糖诱导的脾细胞增殖。REFERENCES1. Wu YW, Jiang YY, Xiao TX, Zh

4、ang HL.Determination of triptonide by cloud point extraction combined with MEKC.J Sep Sci. 2008Mar;31(5):865-71.2. Yao J, Zhang L, Zhao X, Hu L, Jiang Z.Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ioniza

5、tion mass spectrometry.Biol Pharm Bull. 2006 Jul;29(7):1483-6.3. Wang Z, Wen J, Xing J, Guo D.Determination of triptolide and triptonide in human plasma by high-performance liquidchromatography.Biomed Chromatogr. 2005 Jan;19(1):60-2.4. Wang L, Ye W, Hui L, Liu X, Guo Y.Male contraception of triptoni

6、de and its function mechanism.Zhongguo Yi Xue Ke Xue Yuan XueBao. 2000 Jun;22(3):223-6.5. Corson, Timothy W.; Cavga, Hueseyin; Aberle, Nicholas; Crews, Craig M. Triptolide Directly Inhibits dCTP Pyrophosphatase.ChemBioChem (2011), 12(11), 1767-1773.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-