加拿大奶牛肉牛沙门氏菌病

1、沙门氏菌病SalmonellosisPrepared by: Dr. Terry Hunt Translation by: Dr. Fu Xiaoping病因/发病机理 Cause & Pathogenesis伤寒沙门氏菌、都柏林沙门氏菌、新港沙门氏菌Salmonella typhimurium, S. Dublin, S. Newport引起急性败血症、肠炎、慢性肠炎-病菌携带者Cause acute septicemia, enteritis and chronic enteritis carrier state各菌种遍布世界各地Found worldwide in all species

2、偶发或爆发50%发病率，死亡率高，经口/粪传播Can occur sporadically or as outbreaks with 50% morbidity and high mortality Transmitted by fecal/oral route细菌侵入细胞壁、破坏细胞、定居于局部淋巴结中Bacteria invades cell wall, destroys cell and resides in regional lymph nodes危险因素Risk Factors细菌携带者Carrier animals过度拥挤、应激、卫生差、运输、营养不良等Over crowding,

3、 stress, poor hygiene, intensive agriculture, transport and poor nutrition临床症状Clinical Findings败血症Septicemia常见幼龄动物Common in young animals高热、精神萎靡、卧地High fever, depression the recumbency24小时内死亡Many die within 24 hours急性肠炎Acute enteritis常见成年动物Seen in adult cattle水样腹泻Profuse watery diarrhea粪便含有粘膜、血液、上皮脱

4、落物Feces contains mucus, blood, casts and epithelial shreds粪便恶臭Very putrid smell to feces严重脱水、厌食Severe dehydration and anorexia直至卧地、3-4天内死亡Leads to recumbency and death in 3-4 days高死亡率High mortality奶牛经常流产Cows often abort慢性肠炎Chronic enteritis发生于急性病例后Often follows acute enteritis体重下降、生产性能低Weight loss a

5、nd poor doers诊断Diagnosis依据临床症状和细菌培养Based on clinical signs and bacterial culture鉴别诊断Differential Diagnosis犊牛大肠杆菌病Colibacillosis in baby calves球虫病Coccidiosis急性肠阻塞/梗阻Acute intestinal obstruction冬痢Winter dysentery牛病毒性腹泻等BVD/MD后遗症 Sequelae长期生产性能低下Chronic poor doers细菌携带者Carrier animals实验室和病理学诊断Laboratory

6、 and Pathology血液、粪便、牛奶培养Culture feces, blood and milk细菌仅在短期内出现Bacteria is present for only a short time很难鉴定细菌携带者-多重取样Difficult to identify carrier animals multiple samplingPseudodiphtheritic membrane lining distal small intestine从肠系膜淋巴结分离细菌Isolate bacteria from mesenteric lymph nodes治疗Treatment隔离感染牛Isolate infected cattle动物安全程序Biosecurity procedures补液Fluids培养、药敏试验选择抗生素Culture and sensitivity for antibiotic selection预防Prevention & Control好的动物安全条例环境卫生Good Biosec