Fondaparinux-sodium-Fondaparin-sodium-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFondaparinux sodiumCat. No.: HY-B0597CAS No.: 114870-03-0Synonyms: Fondaparin sodium; SR-90107A分式: CHNNaOS分量: 1738.16作靶点: Factor Xa作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mo

2、nth溶解性数据体外实验 H2O : 30 mg/mL (17.26 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 0.5753 mL 2.8766 mL 5.7532 mL5 mM 0.1151 mL 0.5753 mL 1.1506 mL10 mM 0.0575 mL 0.2877 mL 0.5753 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Fondap

3、arinux sodium种抗凝酶依赖性的 factor Xa 抑制剂。IC50 & Target Factor Xa 1体外研究Fondaparinux sodium is the first agent of a new class of anticoagulants that selectively target factor Xa. For1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEFondaparinux, its IC50 values (anti-Xa IU/ml) are 0.590.05 for activated mon

4、ocytes (ac-M) and 0.170.03for monocyte-derived microparticles (MMPs) 2.体内研究 Fondaparinux sodium has a linear, dose-dependent pharmacokinetic profile, which provides a highlypredictable response. Fondaparinux sodium is 100% bioavailable, has a rapid onset of action, and has a half-life of 14 to 16 ho

5、urs, allowing for sustained antithrombotic activity over a 24-hour period. The drug does notaffect prothrombin time or activated partial thromboplastin time, nor does it affect platelet function oraggregation 1.REFERENCES1. Bauer KA. et al. Fondaparinux sodium: a selective inhibitor of factor Xa. Am

6、 J Health Syst Pharm. 2001 Nov 1;58 Suppl 2:S14-7.2. Ben-Hadj-Khalifa S, et al. Differential coagulation inhibitory effect of fondaparinux, enoxaparin and unfractionated heparin in cell modelsof thrombin generation. Blood Coagul Fibrinolysis. 2011 Jul;22(5):369-73.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-