SR0987 - RORγt Agonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESR0987Cat. No.: HY-101454CAS No.: 303126-97-8分式: CHClFNO分量: 397.7作靶点: ROR作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 150 mg/mL (377.17 mM)* means soluble,

2、but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5145 mL 12.5723 mL 25.1446 mL5 mM 0.5029 mL 2.5145 mL 5.0289 mL10 mM 0.2514 mL 1.2572 mL 2.5145 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清

3、的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.29 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.29 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small M

4、olecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (6.29 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 SR0987RORt 的个激动剂，其 EC50 值为800 nM。IC50 & Target EC50: 800 nM (RORt) 1.体外研究 SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of800nM. SR0987 treatment resu

5、lts in a statistically significant reduction of the surface expression of PD-1whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trendtowards increased IL17 production 1.REFERENCES1. Chang MR, et al. Synthetic RORt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0