Ro-46-2005 - Endothelin Receptor Antagonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERo 46-2005Cat. No.: HY-19529CAS No.: 150725-87-4分式: CHNOS分量: 473.54作靶点: Endothelin Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 28 mg/mL (59.13 mM)* means solu

2、ble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1118 mL 10.5588 mL 21.1175 mL5 mM 0.4224 mL 2.1118 mL 4.2235 mL10 mM 0.2112 mL 1.0559 mL 2.1118 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ro 46-2005种新型肽类内素拮抗剂, 抑制管平滑肌细胞(ETA受体), IC50分别为220 nM。R

3、EFERENCES1. Breu V, et al. In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETBreceptors.FEBS Lett. 1993 Nov 15;334(2):210-214.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. Clozel M, et al. Pathophysiological role of endothelin revealed by

4、 the first orally active endothelin receptor antagonist. Nature. 1993 Oct21;365(6448):759-761.3. N.R. Sibson, et al. MRI Determination of the Mechanisms Underlying TNF-a-induced Changes in Cerebral Blood Volume, Tissue WaterDiffusion and BBB Permeability. Proc. Intl. Soc. Mag. Reson. Med. 10 (2002)McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: