N4-Acetylcytidine-triphosphate-ac4CTP-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN4-Acetylcytidine triphosphateCat. No.: HY-111815CAS No.: 1428903-57-4Synonyms: ac4CTP分式: CHNOP分量: 525.19作靶点: NOD-like Receptor (NLR); Endogenous Metabolite作通路: Immunology/Inflammation; Metabolic Enzyme/Protease储存式: Please store

2、 the product under the recommended conditions inthe COA.溶解性数据体外实验 H2O : 250 mg/mL (476.02 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9041 mL 9.5204 mL 19.0407 mL5 mM 0.3808 mL 1.9041 mL 3.8081 mL10 mM 0.1904 mL 0.9520 mL 1.9041 mL请根据产品在不同溶剂中的溶解度，选

3、择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 N4-Acetylcytidine triphosphate种内源性核苷代谢物，源于 tRNA 的降解，可通过诱导 HMGB1 的表达，启动和激活 NLRP3 炎症 1。IC50 & Target NLRP3 Human Endogenous Metabolite体外研究 N4-Acetylcytidine (0.3 mM or 1.0 mM) upregulates NF-B and NLRP3 expression BV2 microglia, and thiscalls for HMGB1

4、 expression and release 1.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEREFERENCES1. Duan J, et al. N4-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. Cell Signal.2019 Mar 7;58:44-52.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021