FPR-Agonist-43-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFPR Agonist 43Cat. No.: HY-19574CAS No.: 903895-98-7分式: CHClNO分量: 384.86作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (324.79 mM; Need ultrasonic)H2O : 90%

2、 corn oilSolubility: 2.08 mg/mL (5.40 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 FPR Agonist 43 (compound 43)是有效的甲酰基肽受体 1 (FPR1) 和甲酰基肽受体 2 (FPR2)/ALX 双重 激动剂 12。IC50 & Target FPR1, FPR2/ALX 1体外研究 FPR Agonist 43 (10-5-107 nM) is actively potent in the cA

3、MP assay in FPR2/ALX over-expressing CHO cells1.FPR Agonist 43 is also active in the GTP binding assay (IC50=20751 nM) 1.FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mousecells 2.Cell Viability Assay 1Cell Line: Chinese hamster ovary (CHO) over-

4、expressing human FPR2/ALX receptorsConcentration: 10-5, 10-3, 0.1, 10, 1000, 105, 107 nMIncubation Time:Result: Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC50=11.61.9 nM).REFERENCES1. Planagum A, et al. Lack of activity of 15-epi-lipoxin A on FPR2/ALX and CysLT1 recept

5、ors in interleukin-8-driven human neutrophil function.Clin Exp Immunol. 2013 Aug;173(2):298-309.2. Forsman H, et al. What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? Scand J Immunol. 2011Sep;74(3):227-234.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58