BML-190-Indomethacin-morpholinylamide-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBML-190Cat. No.: HY-15420CAS No.: 2854-32-2Synonyms: Indomethacin morpholinylamide; IMMA分式: CHClNO分量: 426.89作靶点: Cannabinoid Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mont

2、hs-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (117.13 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3425 mL 11.7126 mL 23.4252 mL5 mM 0.4685 mL 2.3425 mL 4.6850 mL10 mM 0.2343 mL 1.1713 mL 2.3425 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的

3、储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.86 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 BML-190(IMMA)是CB2受体的配体，对CB2和CB1受体的Ki分别为435 nM和 2 M。REFE

4、RENCES1. Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), aninverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences (2. Klegeris, Andis; Bissonnette, Chri

5、stopher J.; McGeer, Patrick L. Reduction of human monocytic cell neurotoxicity and cytokine secretionby ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology (2003), 139(4), 775-786.3. New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP andinositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792