阿尔茨海默症英语介绍市公开课金奖市赛课一等奖课件

1、Alzheimers Disease阿尔茨海默症 第1页Ronald Wilson Reagan罗纳德威尔逊里根第40任（第49-50届）美国总统 president“I know Im on my way to the twilight. I know theres always a bright dawn ahead of the United states. Thank you, my friends. May God bless you forever.”第2页brief introduction01PathogenyTreatment03Clinical manifestation0

2、2Other04Catalog第3页brief introduction1第4页What?Alzheimers disease (AD) is a progressive neurodegenerative disorder .临床症状Clinical symptom记忆障碍dysmnesia失语aphasia失认agnosia执行功效障碍executive dysfunction痴呆dementiaThe disease usually begins after age 60, and risk goes up with age.第5页Two typesAlzheimers disease(

3、AD) 65 years oldsenile dementia(SDAT)65 years old第6页NameIn 1906,AD is named by Dr. Alois Alzheimer, a German doctor. Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness.He found abnormal clumps. Scientists also have found other brain changes in peop

4、le with AD.Nerve cells die in areas of the brain that are vital to memory and other mental abilities.第7页Clinical manifestation2第8页Clinical manifestation期期期death1-3 years2-10 years8-12 yearsMild dementiaModerate dementiaSevere dementiaMore women than men 7:54:6Disease for up to 10-20 years第9页Degradat

5、ion of memory and cognitionWilliam Utermohlen自画像第10页Degradation of memory and cognitionWilliam Utermohlen is an American artist, in 1995 he was diagnosed with Alzheimers disease. Since then, he has decided to take advantage of the limited time available to retain memory and better understand himself

6、 through self portraits.William insisted the 5 New Year paintings self portrait, until completely forgotten how to draw. From the use of skilled drawing, dark portrayal of vivid features, to the same color, shape deformation, self portrait became more and more abstract (pictured above).第11页Degradati

7、on of memory and cognition the effects of Alzheimers disease on the right parietal lobe of the brain are particularly severe, which directly affects the ability of the brain to visualize and develop the ability to draw pictures of the brain.said Dr. Bruce Miller, a neurologist.His work became more a

8、bstract, may be the parietal function damaged, causing blindness.What kind of changes have occurred in the brains of patients with dementia, which is not yet fully understood by the world s academia.第12页PathogenyTreatment3第13页Pathogenesis hypothesis of AD第14页PathogenyAbnormal amyloid beta cell depos

9、ition in neuronsAbnormal phosphorylation of tau proteinvs第15页Beta amyloid (blue curve) and Tau protein (orange curve) Research papers published in recent 30 years第16页Treatmentincrease the concentration of acetylcholine (Ach) in the brainpromoting survival of cholinergic neurons in the brain or improving their nerve conduction functionreducing the production or promoting degradation of beta amyloid第17页Other4第18页Still AliceFilmThe film tells the story of Ali