AV-153-free-base-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAV-153 free baseCat. No.: HY-135218ACAS No.: 19350-66-4分式: CHNO分量: 297.3作靶点: DNA/RNA Synthesis作通路: Cell Cycle/DNA Damage储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 250 mg/mL (840.90 mM;

2、 Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3636 mL 16.8180 mL 33.6361 mL5 mM 0.6727 mL 3.3636 mL 6.7272 mL10 mM 0.3364 mL 1.6818 mL 3.3636 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根

3、据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.00 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (7.00 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 AV-1

4、53 free base种 1,4-dihydropyridine (1,4-DHP) 衍物，具有抗突变作。在体外细胞内，AV-153free base 可以插到 DNA 的单链断裂处，减少 DNA 损伤并刺激 DNA 修复。AV-153 free base 可以与胸腺嘧啶和胞嘧啶相互作，对聚 (ADP) 核糖化有响。AV-153 free base 具有抗癌活性。体外研究 AV-153 free base causes IC50s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively 1.AV-153 free base

5、(1 nM to 10 M; 3 hours) reduces the level of spontaneously arising DNA single-strandbreaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 1367% 1.REFERENCES1. Nadezhda I Ryabokon, et al. A 1,4-dihydropyridine Derivative Reduces DNA Damage and Stimulates DNA Repair in Human Cells inVitro. M

6、utat Res. 2005 Nov 10;587(1-2):52-8.2. E Buraka, et al. DNA-binding Studies of AV-153, an Antimutagenic and DNA Repair-Stimulating Derivative of 1,4-dihydropiridine. ChemBiol Interact. 2014 Sep 5;220:200-7.3. Lidija Milkovic, et al. Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-LikeCells In Vitro. Antioxidants (Basel). 2018 Sep 19;7(9):123.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te