基于大分子的肿瘤靶向药物控释课件

NorthwesternPolytechnicUniversity基于大分子的药物控释肿瘤靶向PolymericTumor-TargetingDrugControlledReleaseNorthwesternPolytechnicUniveDrugLoad装载定位TargetingDrugRelease释放DrugLoad装载定位TargetingDrugRel胶束Micelles树枝状聚合物DendrimersLiposomes微脂囊聚合物-药物偶联物Polymer-drugconjugatesDrugLoad装载胶束Micelles树枝状聚合物DendrimersLipo定位主动active被动passiveTargeting配合基-受体Ligand-receptorEPR效应EPREffect叶酸cRGD定位主动active被动passiveTargeting配合正常组织癌变部位正常组织癌变部位DrugRelease释放pH温度降解磁场UV电场内因外因PDEAEMAPNIPAM-s-s-hydrazonebondsDrugRelease释放pH温度降解磁场UV电场内因外因多层分子设计MolecularDesign嵌段分子量端基ATRPRAFT点击化学超分子星形开环多层分子设计MolecularDesign嵌段分子量端基ATumor-TargetingPeptideConjugatedpH-ResponsiveMicellesasaPotentialDrugCarrierforCancerTherapyXiangLanWu,JongHoKimTumor-TargetingPeptideConjugTumor-Targeting,pH-Responsive,andStableUnimolecularMicellesasDrugNanocarriersforTargetedCancerTherapyXiaoqiangYang,JamisonJ.Grailer,SrikanthPillaTumor-Targeting,pH-ResponsivePEG-SS-PPS:Reduction-SensitiveDisulfideBlockCopolymerVesiclesforIntracellularDrugDeliveryXiangLanWu,JongHoKimPEG-SS-PPS:Reduction-SensitivFolate-ConjugatedThermoresponsiveBlockCopolymers:HighlyEfficientConjugationandSolutionSelf-AssemblyPriyadarsiDe,SudershanR.Gondi,andBrentS.SumerlinFolate-ConjugatedThermoresponDevelopmentofmultiple-layerpolymericparticlesfortargetedandcontrolleddrugdeliveryBhanuprasanthKoppolu,MS,MahamRahim,Developmentofmultiple-layerOSiOSiOSiSiOSiOSiSiOSiOSiOSiOSiHSiOSiOSiHOSiOSiHSiOSiHNH2NHNH2NHNH2NHNNH2graftedPNIPAMShellβ-CDbasedHBPCoreThermo-ResponsiveHyperbranchedpoly(β-CD)s-g-PNIPAMOSiOSiOSiSiOSiOSiSiOSiOSiOSiOSThankyou!PolymericTumor-Targ