Cetylpyridinium-chloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemECetylpyridiniumchlorideCat.No.:HY-B1464CASNo.:123-03-5分⼦式:C₂₁H₃₈ClN分⼦量:339.99作⽤靶点:Bacterial;HBV作⽤通路:Anti-infection储存⽅式:4°C,storedundernitrogen,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen,awayfrommoisture)溶解性数据体外实验DMSO:100mg/mL(294.13mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.9413mL14.7063mL29.4126mL5mM0.5883mL2.9413mL5.8825mL10mM0.2941mL1.4706mL2.9413mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性Cetylpyridiniumchloride，⼀种阳离⼦季铵化合物，⼀种具有⼴谱活性的抗剂。Cetylpyridiniumchloride⼀种有效的抗HBV⾐装配抑制剂，IC50为2.5μM。Cetylpyridiniumchloride被⽤于杀⾍剂和各种漱⼝⽔以及其他个⼈护理产品中。IC50&TargetIC50:2.5μM(HBVcapsidassembly)[1]体外研究Cetylpyridiniumchlorideinteractswithdimericviralnucleocapsidprotein(knownascoreproteinorHBcAg)specifically.ComparedwithotherHBVinhibitors,Cetylpyridiniumchlorideachievessignificantlybetter1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEreductionofHBVparticlenumberinHepG2.2.15cellline.CetylpyridiniumchlorideinhibitscapsidassemblyandleadstoreducedHBVbiogenesis[1].Cetylpyridiniumchlorideisasafeantimicrobialagentwithbroad-spectrumactivityforpreventingbiofilmformationandgingivitis[2].体内研究Cetylpyridiniumchloride(30μg/kg;intramuscularinjection;daily;for3days;maleC57BL/6mice)treatmentinhibitsHBVreplicationinmousehydrodynamicmodelsystem[1].AnimalModel:MaleC57BL/6mice(6-weekold)injectedwiththeplasmid[1]Dosage:272ꢀμg/kg/dayAdministration:Intramuscularinjection;daily;for3daysResult:SuppressedserumHBVDNAlevels,decreasedby60%inday2and45%inday3comparedtothecontrol.REFERENCES[1].HyunWookSeo,etal.CetylpyridiniumchlorideinteractionwiththehepatitisBviruscoreproteininhibitscapsidassembly.VirusRes.2019Apr2;263:102-111.[2].HirotoImai,etal.Cetylpyridiniumchlorideatsublethallevelsincreasesthesusceptibilityofratthymiclymphocytestooxidativestress.Chemosphere.2017Mar;170:118-123.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuse