H3B-120-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEH3B-120Cat.No.:HY-136128CASNo.:2194903-42-7分⼦式:C₁₉H₂₄N₄O₂S分⼦量:372.48作⽤靶点:PotassiumChannel作⽤通路:MembraneTransporter/IonChannel储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:62.5mg/mL(167.79mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.6847mL13.4235mL26.8471mL5mM0.5369mL2.6847mL5.3694mL10mM0.2685mL1.3424mL2.6847mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(5.58mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(5.58mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(5.58mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性H3B-120⼀种⾼选择性，竞争性和变构的氨甲酰磷酸合成酶1(CPS1)抑制剂，IC50为1.5μM，Ki为1.4μM。H3B-120具有抗癌活性。IC50&TargetIC50:1.5μM(CPS1)[1]Ki:1.4μM(CPS1)[1]体外研究H3B-120hasnoinhibitionofCPS2activityofCAD(CPS2,aspartyltranscarbamylase,dihydroorotase)[1].H3B-120achievesinhibitionbybindingtoanallostericpocketsituatedbetweentheintegratingandATPAdomains[1].H3B-120(25,50,75,100μM)inhibitsureaproductioninadose-dependentmanner,althoughthecellularpotencydecreasessignificantlycomparedwithenzymaticassays[1].Thehalf-lifeofH3B-120isonly40min[1].REFERENCES[1].YaoS,etal.SmallMoleculeInhibitionofCPS1ActivitythroughanAllostericPocket.CellChemBiol.2020Mar19;27(3):259-268.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-