O-O-Dimethyl-cannabigerol-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEO,O-Dimethyl-cannabigerolCat.No.:HY-137960CASNo.:29106-16-9分⼦式:C₂₃H₃₆O₂分⼦量:344.53作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:55mg/mL(159.64mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.9025mL14.5125mL29.0250mL5mM0.5805mL2.9025mL5.8050mL10mM0.2903mL1.4513mL2.9025mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:2.75mg/mL(7.98mM);Suspendedsolution;Needultrasonic2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.75mg/mL(7.98mM);Suspendedsolution;Needultrasonic3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.75mg/mL(7.98mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性O,O-Dimethyl-cannabigerol⼀种可从⼤⿇中提取的天然物质。O,O-Dimethyl-cannabigerol对⾦⾊葡萄球耐药株具有抗作⽤(MIC范为1-2μg/mL)。O,O-Dimethyl-cannabigerol属于⾮精神活性物质[2][3]。体外研究O,O-Dimethyl-cannabigerol(compound1)inhibitsKBcellsgrowthwithIC50sof44.55μM(MTTassay)and69.4μM(SRBassay)[2].O,O-Dimethyl-cannabigerol(0-100μM;48hours)inducescellcytotoxicinNIH3T3fibroblasts,withCD50sof60.46μM(MTTassay)and82.98μM(SRBassay)[2].O,O-Dimethyl-cannabigerolshowsantitumorefficacyagainstmelanomacellsofamouse'sskinwithanIC50of31.3μM[2].CellCytotoxicityAssay[2]CellLine:NIH3T3fibroblastsConcentration:0,1,25,50,100μMIncubationTime:48hoursResult:InducedcellcytotoxicwithCD50sof60.46μM(MTTassay)and82.98μM(SRBassay)REFERENCES[1].HanDS,etal.Synthesisandcytotoxiceffectsofdeoxy-tomentellin.ArchPharmRes.2000;23(2):121-127.[2].CaprioglioD,etal.O-MethylPhytocannabinoids:Semi-synthesis,AnalysisinCannabisFlowerheads,andBiologicalActivity.PlantaMed.2019;85(11-12):981-986.[3].AppendinoG,etal.AntibacterialcannabinoidsfromCannabissativa:astructure-activitystudy.JNatProd.2008;71(8):1427-1430.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forr