Ezurpimtrostat-hydrochloride-GNS561-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEEzurpimtrostathydrochlorideCat.No.:HY-137978ACASNo.:1914148-73-4Synonyms:GNS561hydrochloride分⼦式:C₂₅H₃₂Cl₂N₄分⼦量:459.45作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:8.33mg/mL(18.13mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1765mL10.8826mL21.7652mL5mM0.4353mL2.1765mL4.3530mL10mM0.2177mL1.0883mL2.1765mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Ezurpimtrostathydrochloride(compound2-3)⼀种⼝服有效的抗纤维化剂。Ezurpimtrostathydrochloride能明显减轻DEN(⼆⼄亚硝胺)肝硬化⼤⿏的肝纤维化。Ezurpimtrostathydrochloride可⽤于纤维化、癌症、⾃噬和CTSB、CTSL和CTSD相关的疾病研究[1]。体内研究Ezurpimtrostathydrochloride(compound2-3)(15mg/kg/day,PO,for6weeks)significantlyreducesthearea1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEofliverfibrosisandthelevelofcollagenfibersdeposition(by41.0%)inDENcirrhoticratmodel[1].REFERENCES[1].PhilippeHalfon,etal.Substituted2,4diamino-quinolineasnewmedicamentforfibrosis,autophagyandcathepsinsb(ctsb),l(ctsl)andd(ctsd)relateddiseases.EP3620164A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02